Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMIZB81)

Drug Name

Pyrazine-2-carboxylic acid adamantan-1-ylamide Drug Info

Synonyms

CHEMBL253348; Pyrazine-2-carboxylic acid adamantan-1-ylamide; BAS 03365795; AC1MG7YQ; Cambridge id 7248781; Oprea1_265306; Oprea1_647087; MLS000088554; cid_2931812; MolPort-001-540-487; HMS2379I12; ZINC4197514; N-adamantanylpyrazin-2-ylcarboxamide; N-1-adamantyl-2-pyrazinecarboxamide; BDBM50231727; STK431969; AKOS000665660; N-(1-adamantyl)pyrazine-2-carboxamide; SDCCGMLS-0024327.P002; MCULE-4724742312; SMR000071836; ST50923663

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 2931812
TTD Drug ID: DMIZB81

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Metabotropic glutamate receptor 1 (mGluR1)	TTVBPDM	GRM1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Metabotropic glutamate receptor 1 (mGluR1)	DTT	GRM1	3.888	3.848	3.711	3.678

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Metabotropic glutamate receptor 1 (mGluR1)	DTT	GRM1	2.31E-01	-0.05	-0.2
Metabotropic glutamate receptor 1 (mGluR1)	DTT	GRM1	2.46E-02	0.11	0.74

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Positive and negative modulation of group I metabotropic glutamate receptors. J Med Chem. 2008 Feb 14;51(3):634-47.