Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMJ29MN)

Drug Name

N-benzyl-2-oxo-2H-chromene-3-carboxamide Drug Info

Synonyms

3-(Benzylcarbamoyl)coumarin; BRN 0257384; Coumarin, 3-(benzylcarbamoyl)-; 2H-1-Benzopyran-3-carboxamide, 2-oxo-N-(phenylmethyl)-; 1846-90-8; 2-Oxo-2H-chromene-3-carboxylic acid benzylamide; 2-Oxo-N-(phenylmethyl)-2H-1-benzopyran-3-carboxamide; N-benzyl-2-oxo-2H-chromene-3-carboxamide; AC1L3R3J; Oprea1_583472; Oprea1_560940; 3-carboxamido coumarin, 36; MLS001210650; CHEMBL469976; CTK0H5459; BDBM29186; DTXSID90171596; MolPort-000-375-285; ZINC130283; HMS2837I12; STK078064; N-benzyl-2-oxochromene-3-carboxamide; AKOS002234224

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 120587
CAS Number: CAS 1846-90-8
TTD Drug ID: DMJ29MN

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Monoamine oxidase type B (MAO-B)	DTT	MAOB	9.367	6.907	8.237	8.409

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Monoamine oxidase type B (MAO-B)	DTT	MAOB	2.65E-02	1.12E-02	0.07

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins. J Med Chem. 2009 Apr 9;52(7):1935-42.