Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMJ432G)

Drug Name

GMI-1070 Drug Info

Synonyms

GMI-1010; GMI-1011; GMI-1040 series; GMI-1077; Glyosin, GlycoMimetics; Heterobifunctional glycomimetic pan-selectin inhibitors (smallmolecule therapeutic), GlycoMimetics; Selectin inhibitors (asthma/sickle cell anemia/hematological neoplasm), GlycoMimetics

Indication

Disease Entry	ICD 11	Status	REF
Asthma	CA23	Phase 3	[1]
Vaso-occlusive crisis	BE2Y	Phase 3	[2]

Cross-matching ID

PubChem CID: 44232546
CAS Number: CAS 927881-99-0
TTD Drug ID: DMJ432G

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
E-selectin (SELE)	TTAU4D6	LYAM2_HUMAN	Inhibitor	[3]
L-selectin (SELL)	TT2IYXF	LYAM1_HUMAN	Inhibitor	[3]
P-selectin (SELP)	TTE5VG0	LYAM3_HUMAN	Inhibitor	[3]
Selectin (SEL)	TTBGONL	NOUNIPROTAC	Antagonist	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
P-selectin (SELP)	DTT	SELP	7.304	7.427	7.315	7.849
E-selectin (SELE)	DTT	SELE	5.194	3.307	3.104	5.907
L-selectin (SELL)	DTT	SELL	6.2	6.209	6.154	5.963

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Asthma

ICD Disease Classification

CA23

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
E-selectin (SELE)	DTT	SELE	6.43E-04	0.02	0.12

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8307).
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Deal watch: Pfizer deal for selectin inhibitor highlights potential of glycomimetic drugs. Nat Rev Drug Discov. 2011 Dec 1;10(12):890.