Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMJ52FZ)

Drug Name
EPI-2010 Drug Info
Indication
Disease Entry ICD 11 Status REF
Asthma CA23 Discontinued in Phase 2 [1]
Therapeutic Class
Antisense
Cross-matching ID
PubChem CID
146032860
TTD Drug ID
DMJ52FZ

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
ADORA1 messenger RNA (ADORA1 mRNA) TT92EIB AA1R_HUMAN Not Available [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
ADORA1 messenger RNA (ADORA1 mRNA) DTT ADORA1 4.698 5.291 5.298 4.797
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 12 Disease of the respiratory system
Disease Class ICD-11: CA23 Asthma
The Studied Tissue Nasal and bronchial airway
The Studied Disease Asthma [ICD-11:CA23]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
ADORA1 messenger RNA (ADORA1 mRNA) DTT ADORA1 1.74E-01 -0.13 -0.36
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009338)
2 RASONs: a novel antisense oligonucleotide therapeutic approach for asthma. Expert Opin Biol Ther. 2001 Nov;1(6):979-83.