Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMJI3BA)

Drug Name
Peginterferon alfa-2a Drug Info
Synonyms Pegasys; Peginterferon alfa-2a (genetical recombination); Peginterferon alfa-2a (USAN/INN); Peginterferon alfa-2a (genetical recombination) (JAN)
Indication
Disease Entry ICD 11 Status REF
Chronic hepatitis B virus infection Approved [1]
Hairy cell leukaemia 2A82.2 Approved [2]
Leukemia Approved [3]
Therapeutic Class
Anticancer Agents
Cross-matching ID
TTD Drug ID
DMJI3BA
VARIDT Drug ID
DR00472

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interferon-alpha 2 (IFNA2) TTSIUJ9 IFNA2_HUMAN Modulator [4]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Interferon-alpha 2 (IFNA2) DTT IFNA2 2.609 1.678 0.263 0.379
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Chronic hepatitis B virus infection
ICD Disease Classification
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Interferon-alpha 2 (IFNA2) DTT IFNA2 9.31E-04 0.35 2.05
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Entecavir and Peginterferon Alfa-2a in Adults With Hepatitis B e Antigen-Positive Immune-Tolerant Chronic Hepatitis B Virus Infection. Hepatology. 2019 Jun;69(6):2338-2348.
2 Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
3 Imatinib plus peginterferon alfa-2a in chronic myeloid leukemia. N Engl J Med. 2010 Dec 23;363(26):2511-21.
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.