Details of the Drug

General Information of Drug (ID: DMJI3BA)

Drug Name
Peginterferon alfa-2a
Synonyms Pegasys; Peginterferon alfa-2a (genetical recombination); Peginterferon alfa-2a (USAN/INN); Peginterferon alfa-2a (genetical recombination) (JAN)
Indication
Disease Entry ICD 11 Status REF
Chronic hepatitis B virus infection N.A. Approved [1]
Hairy cell leukaemia 2A82.2 Approved [2]
Leukemia N.A. Approved [3]
Therapeutic Class
Anticancer Agents
Sequence
CDLPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFGFPQEEFGNQFQKAETIPVLHEMI
QQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVR
KYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQESLRSKE
ADMET Property
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 72-96 h []
Clearance
The sytemic clearance of drug is 94 mL/h []
Half-life
The concentration or amount of drug in body reduced by one-half in 84 - 353 hours []
Cross-matching ID
DrugBank ID
DB00008
TTD ID
D0Y8OK
VARIDT ID
DR00472
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interferon-alpha 2 (IFNA2) TTSIUJ9 IFNA2_HUMAN Modulator [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Interferon lambda-3 (IFNL3) OTPIMGAU IFNL3_HUMAN Drug Response [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Chronic hepatitis B virus infection
ICD Disease Classification
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Interferon-alpha 2 (IFNA2) DTT IFNA2 9.31E-04 0.35 2.05
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Peginterferon alfa-2a
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Cladribine DM3JDRP Major Additive immunosuppressive effects by the combination of Peginterferon alfa-2a and Cladribine. Mature B-cell leukaemia [2A82] [6]
Idelalisib DM602WT Moderate Increased risk of hepatotoxicity by the combination of Peginterferon alfa-2a and Idelalisib. Mature B-cell leukaemia [2A82] [7]
Alemtuzumab DMZL3IV Moderate Additive immunosuppressive effects by the combination of Peginterferon alfa-2a and Alemtuzumab. Mature B-cell leukaemia [2A82] [8]
Coadministration of a Drug Treating the Disease Different from Peginterferon alfa-2a (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Remdesivir DMBFZ6L Moderate Increased risk of hepatotoxicity by the combination of Peginterferon alfa-2a and Remdesivir. 1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019] [9]
Thioguanine DM7NKEV Moderate Increased risk of hepatotoxicity by the combination of Peginterferon alfa-2a and Thioguanine. Acute myeloid leukaemia [2A60] [10]
Bedaquiline DM3906J Moderate Increased risk of hepatotoxicity by the combination of Peginterferon alfa-2a and Bedaquiline. Antimicrobial drug resistance [MG50-MG52] [11]
Aminophylline DML2NIB Moderate Decreased metabolism of Peginterferon alfa-2a caused by Aminophylline mediated inhibition of CYP450 enzyme. Asthma [CA23] [9]
Roflumilast DMPGHY8 Moderate Additive immunosuppressive effects by the combination of Peginterferon alfa-2a and Roflumilast. Asthma [CA23] [6]
Pexidartinib DMS2J0Z Major Increased risk of hepatotoxicity by the combination of Peginterferon alfa-2a and Pexidartinib. Bone/articular cartilage neoplasm [2F7B] [12]
Levobupivacaine DM783CH Moderate Decreased metabolism of Peginterferon alfa-2a caused by Levobupivacaine mediated inhibition of CYP450 enzyme. Corneal disease [9A76-9A78] [6]
Oxtriphylline DMLHSE3 Moderate Decreased metabolism of Peginterferon alfa-2a caused by Oxtriphylline mediated inhibition of CYP450 enzyme. Cough [MD12] [9]
PMID27977313-Compound-29 DMIF7KG Moderate Increased risk of hepatotoxicity by the combination of Peginterferon alfa-2a and PMID27977313-Compound-29. Discovery agent [N.A.] [13]
PMID28870136-Compound-48 DMPIM9L Moderate Decreased metabolism of Peginterferon alfa-2a caused by PMID28870136-Compound-48 mediated inhibition of CYP450 enzyme. Discovery agent [N.A.] [9]
Stiripentol DMMSDOY Moderate Decreased metabolism of Peginterferon alfa-2a caused by Stiripentol mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [6]
Cannabidiol DM0659E Moderate Increased risk of hepatotoxicity by the combination of Peginterferon alfa-2a and Cannabidiol. Epileptic encephalopathy [8A62] [6]
Brentuximab vedotin DMWLC57 Moderate Increased risk of peripheral neuropathy by the combination of Peginterferon alfa-2a and Brentuximab vedotin. Hodgkin lymphoma [2B30] [14]
Efavirenz DMC0GSJ Moderate Increased risk of hepatotoxicity by the combination of Peginterferon alfa-2a and Efavirenz. Human immunodeficiency virus disease [1C60-1C62] [15]
Mipomersen DMGSRN1 Major Increased risk of hepatotoxicity by the combination of Peginterferon alfa-2a and Mipomersen. Hyper-lipoproteinaemia [5C80] [16]
Teriflunomide DMQ2FKJ Major Increased risk of hepatotoxicity by the combination of Peginterferon alfa-2a and Teriflunomide. Hyper-lipoproteinaemia [5C80] [17]
BMS-201038 DMQTAGO Major Increased risk of hepatotoxicity by the combination of Peginterferon alfa-2a and BMS-201038. Hyper-lipoproteinaemia [5C80] [18]
Ramelteon DM7IW9J Moderate Decreased metabolism of Peginterferon alfa-2a caused by Ramelteon mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [19]
Polyethylene glycol DM4I1JP Moderate Increased risk of lowers seizure threshold by the combination of Peginterferon alfa-2a and Polyethylene glycol. Irritable bowel syndrome [DD91] [20]
Methotrexate DM2TEOL Moderate Increased risk of hepatotoxicity by the combination of Peginterferon alfa-2a and Methotrexate. Leukaemia [2A60-2B33] [6]
Denosumab DMNI0KO Moderate Additive immunosuppressive effects by the combination of Peginterferon alfa-2a and Denosumab. Low bone mass disorder [FB83] [21]
Calaspargase pegol DMQZBXI Moderate Increased risk of hepatotoxicity by the combination of Peginterferon alfa-2a and Calaspargase pegol. Malignant haematopoietic neoplasm [2B33] [13]
Clofarabine DMCVJ86 Moderate Increased risk of hepatotoxicity by the combination of Peginterferon alfa-2a and Clofarabine. Mature B-cell lymphoma [2A85] [22]
Thalidomide DM70BU5 Moderate Increased risk of peripheral neuropathy by the combination of Peginterferon alfa-2a and Thalidomide. Multiple myeloma [2A83] [23]
Bortezomib DMNO38U Moderate Increased risk of peripheral neuropathy by the combination of Peginterferon alfa-2a and Bortezomib. Multiple myeloma [2A83] [23]
Interferon beta-1a DM1A6RV Moderate Increased risk of hepatotoxicity by the combination of Peginterferon alfa-2a and Interferon beta-1a. Multiple sclerosis [8A40] [24]
Tecfidera DM2OVDT Moderate Additive immunosuppressive effects by the combination of Peginterferon alfa-2a and Tecfidera. Multiple sclerosis [8A40] [25]
Siponimod DM2R86O Major Additive immunosuppressive effects by the combination of Peginterferon alfa-2a and Siponimod. Multiple sclerosis [8A40] [9]
Fingolimod DM5JVAN Major Additive immunosuppressive effects by the combination of Peginterferon alfa-2a and Fingolimod. Multiple sclerosis [8A40] [26]
Interferon beta-1b DMCN61Z Moderate Increased risk of hepatotoxicity by the combination of Peginterferon alfa-2a and Interferon beta-1b. Multiple sclerosis [8A40] [24]
Ocrelizumab DMEZ2KH Moderate Additive immunosuppressive effects by the combination of Peginterferon alfa-2a and Ocrelizumab. Multiple sclerosis [8A40] [27]
Ozanimod DMT6AM2 Major Additive immunosuppressive effects by the combination of Peginterferon alfa-2a and Ozanimod. Multiple sclerosis [8A40] [6]
Bupropion DM5PCS7 Major Increased risk of lowers seizure threshold by the combination of Peginterferon alfa-2a and Bupropion. Nicotine use disorder [6C4A] [28]
Tramadol DMRQD04 Major Increased risk of lowers seizure threshold by the combination of Peginterferon alfa-2a and Tramadol. Pain [MG30-MG3Z] [29]
Rasagiline DM3WKQ4 Moderate Decreased metabolism of Peginterferon alfa-2a caused by Rasagiline mediated inhibition of CYP450 enzyme. Parkinsonism [8A00] [9]
Ropinirole DMA6S1D Moderate Decreased metabolism of Peginterferon alfa-2a caused by Ropinirole mediated inhibition of CYP450 enzyme. Parkinsonism [8A00] [30]
Lindane DMB8CNL Moderate Increased risk of lowers seizure threshold by the combination of Peginterferon alfa-2a and Lindane. Pediculosis [1G00] [31]
Leflunomide DMR8ONJ Major Additive immunosuppressive effects by the combination of Peginterferon alfa-2a and Leflunomide. Rheumatoid arthritis [FA20] [17]
Asenapine DMSQZE2 Moderate Decreased metabolism of Peginterferon alfa-2a caused by Asenapine mediated inhibition of CYP450 enzyme. Schizophrenia [6A20] [32]
Pimozide DMW83TP Moderate Decreased metabolism of Peginterferon alfa-2a caused by Pimozide mediated inhibition of CYP450 enzyme. Schizophrenia [6A20] [33]
Trabectedin DMG3Y89 Moderate Increased risk of hepatotoxicity by the combination of Peginterferon alfa-2a and Trabectedin. Solid tumour/cancer [2A00-2F9Z] [6]
Epirubicin DMPDW6T Moderate Increased risk of hepatotoxicity by the combination of Peginterferon alfa-2a and Epirubicin. Solid tumour/cancer [2A00-2F9Z] [9]
Naltrexone DMUL45H Moderate Increased risk of hepatotoxicity by the combination of Peginterferon alfa-2a and Naltrexone. Substance abuse [6C40] [34]
Anagrelide DMSQ8MD Moderate Decreased metabolism of Peginterferon alfa-2a caused by Anagrelide mediated inhibition of CYP450 enzyme. Thrombocytosis [3B63] [35]
Tizanidine DMR2IQ4 Major Decreased metabolism of Peginterferon alfa-2a caused by Tizanidine mediated inhibition of CYP450 enzyme. Tonus and reflex abnormality [MB47] [36]
Azathioprine DMMZSXQ Moderate Additive immunosuppressive effects by the combination of Peginterferon alfa-2a and Azathioprine. Transplant rejection [NE84] [9]
Ganciclovir DM1MBYQ Moderate Additive myelosuppressive effects by the combination of Peginterferon alfa-2a and Ganciclovir. Virus infection [1A24-1D9Z] [9]
Valganciclovir DMS2IUH Moderate Additive myelosuppressive effects by the combination of Peginterferon alfa-2a and Valganciclovir. Virus infection [1A24-1D9Z] [9]
⏷ Show the Full List of 48 DDI Information of This Drug

References

1 Entecavir and Peginterferon Alfa-2a in Adults With Hepatitis B e Antigen-Positive Immune-Tolerant Chronic Hepatitis B Virus Infection. Hepatology. 2019 Jun;69(6):2338-2348.
2 Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
3 Imatinib plus peginterferon alfa-2a in chronic myeloid leukemia. N Engl J Med. 2010 Dec 23;363(26):2511-21.
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5 Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for IFNL3 (IL28B) genotype and PEG interferon--based regimens. Clin Pharmacol Ther. 2014 Feb;95(2):141-6. doi: 10.1038/clpt.2013.203. Epub 2013 Oct 4.
6 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
7 Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
8 Product Information. Campath (alemtuzumab) Berlex, Richmond, CA.
9 Cerner Multum, Inc. "Australian Product Information.".
10 Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
11 Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
12 Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
13 Al-Nawakil C, Willems L, Mauprivez C, et.al "Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors." Leuk Lymphoma 55 (2014): 1670-4. [PMID: 24090500]
14 Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.
15 Elsharkawy AM, Schwab U, McCarron B, et al. "Efavirenz induced acute liver failure requiring liver transplantation in a slow drug metaboliser." J Clin Virol 58 (2013): 331-3. [PMID: 23763943]
16 Product Information. Kynamro (mipomersen). Genzyme Corporation, Cambridge, MA.
17 Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
18 Product Information. Juxtapid (lomitapide). Aegerion Pharmaceuticals Inc, Cambridge, MA.
19 Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
20 Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
21 Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
22 Product Information. Clolar (clofarabine). sanofi-aventis, Bridgewater, NJ.
23 Argov Z, Mastaglia FL "Drug-induced peripheral neuropathies." Br Med J 1 (1979): 663-6. [PMID: 219931]
24 Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
25 Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
26 Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
27 Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
28 Product Information. Wellbutrin XL (buPROPion). GlaxoSmithKline, Philadelphia, PA.
29 Product Information. Ultram (tramadol). McNeil Pharmaceutical, Raritan, NJ.
30 Product Information. Noroxin (norfloxacin). Merck & Co, Inc, West Point, PA.
31 Matsuoka LY "Convulsions following application of gamma benzene hexachloride." J Am Acad Dermatol 5 (1981): 98-9. [PMID: 6168673]
32 Product Information. Saphris (asenapine). Schering-Plough Corporation, Kenilworth, NJ.
33 Krahenbuhl S, Sauter B, Kupferschmidt H, Krause M, Wyss PA, Meier PJ "Case report: reversible QT prolongation with torsades de pointes in a patient with pimozide intoxication." Am J Med Sci 309 (1995): 315-6. [PMID: 7771501]
34 Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
35 Product Information. Agrylin (anagrelide). Roberts Pharmaceutical Corporation, Eatontown, NJ.
36 Granfors MT, Backman JT, Laitila J, Neuvonen PJ "Tizanidine is mainly metabolized by cytochrome P450 1A2 in vitro." Br J Clin Pharmacol 57 (2004): 349-53. [PMID: 14998432]