Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMJQ7XD)

Drug Name

Recombinant TSH superagonists Drug Info

Synonyms

Recombinant TSH superagonists (thyroid cancer); TR-1401; TR-1402; Recombinant TSH superagonists (thyroid cancer), Trophogen; TSH superagonist (thyroid cancer/goiter), Trophogen; Thyroid stimulating hormone superagonist (thyroid cancer/goiter), Trophogen

Indication

Disease Entry	ICD 11	Status	REF
Thyroid cancer	2D10	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMJQ7XD

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thyrotropin receptor (TSHR)	TT6NYJA	TSHR_HUMAN	Agonist	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Thyrotropin receptor (TSHR)	DTT	TSHR	2.036	2.406	0.848	2.585

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification

02 Neoplasm

Disease Class

ICD-11: 2C82 Prostate cancer

The Studied Tissue

Thyroid

The Studied Disease

Thyroid cancer [ICD-11:2C82]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Thyrotropin receptor (TSHR)	DTT	TSHR	9.30E-18	-0.72	-1

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 255).