Details of the Drug

General Information of Drug (ID: DMJQ7XD)

• Drug Name: Recombinant TSH superagonists
• Synonyms: Recombinant TSH superagonists (thyroid cancer); TR-1401; TR-1402; Recombinant TSH superagonists (thyroid cancer), Trophogen; TSH superagonist (thyroid cancer/goiter), Trophogen; Thyroid stimulating hormone superagonist (thyroid cancer/goiter), Trophogen

Indication

Disease Entry	ICD 11	Status	REF
Thyroid cancer	2D10	Investigative	[1]

• Cross-matching ID: TTD ID: D0U2DY

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thyrotropin receptor (TSHR)	TT6NYJA	TSHR_HUMAN	Agonist	[1]

Molecular Expression Atlas of This Drug

• ICD Disease Classification: 02 Neoplasm
• Disease Class: ICD-11: 2C82 Prostate cancer
• The Studied Tissue: Thyroid
• The Studied Disease: Thyroid cancer [ICD-11:2C82]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Thyrotropin receptor (TSHR)	DTT	TSHR	9.30E-18	-0.72	-1

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 255).