Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMK6CD9)

Drug Name

2-(3-Chloro-phenyl)-1H-[1,8]naphthyridin-4-one Drug Info

Synonyms

CHEMBL45677; NSC679034; AC1L8S0S; 1, 2-(3-chlorophenyl)-; 2-(3-Chloro-phenyl)-1H-[1,8]naphthyridin-4-one; SCHEMBL7920166; CTK8C9853; ZINC5541496; BDBM50059959; NSC-679034; NCI60_028233; 2-(3-chlorophenyl)-1H-1,8-naphthyridin-4-one; 2-(3-Chlorophenyl)-1,8-naphthyridin-4(1H)-one; 1,8-Naphthyridin-4(1H)-one, 2-(3-chlorophenyl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 386586
TTD Drug ID: DMK6CD9

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tubulin (TUB)	TTML2WA	NOUNIPROTAC	Inhibitor	[1]
Tubulin beta (TUBB)	TTYFKSZ	NOUNIPROTAC	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tubulin (TUB)	DTT	TUB	7.743	8.411	8.625	8.347

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tubulin (TUB)	DTT	NO-GeName	7.94E-02	0.35	0.43

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubul... J Med Chem. 1997 Sep 12;40(19):3049-56.