Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMKB2P8)

Drug Name

2-methylbut-3-yn-2-yl 4-methoxybenzoate Drug Info

Synonyms

2-methylbut-3-yn-2-yl 4-methoxybenzoate; 294619-87-7; 1,1-dimethyl-2-propyn-1-yl 4-methoxybenzoate; ZERO/003209; AC1LE8OG; ARONIS020757; CHEMBL244918; ZINC96414; BDBM23726; KS-00004CEK; MolPort-001-510-482; BBL014263; STK001780; AKOS000487782; MCULE-8443375339; ST036671; 1,1-dimethylprop-2-ynyl 4-methoxybenzoate; BB0275130; 1,1-dimethyl-2-propynyl 4-methoxybenzoate; H2604; EU-0085447; SR-01000525786; AG-205/12908103; SR-01000525786-1; 1,1-dimethylprop-2-yn-1-yl 4-methoxybenzoate, 10; 4-Methoxybenzoic acid 1,1-dimethyl-2-propynyl es

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 708205
TTD Drug ID: DMKB2P8

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neutrophil elastase (NE)	TTPLTSQ	ELNE_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Neutrophil elastase (NE)	DTT	ELANE	2.379	2.036	1.379	2.945

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Neutrophil elastase (NE)	DTT	ELANE	2.35E-01	-0.55	-0.82

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem. 2007 Oct 4;50(20):4928-38.