Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMKCT0M)

Drug Name
AX-9657 Drug Info
Synonyms Neutrophil elastase inhibitors (lung disease); HNE inhibitors (lung disease), Kyorin; Neutrophil elastase inhibitors (lung disease), Kyorin
Indication
Disease Entry ICD 11 Status REF
Pulmonary disease 1B10-1F85 Investigative [1]
Cross-matching ID
PubChem CID
25205741
CAS Number
CAS 1015439-77-6
TTD Drug ID
DMKCT0M

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Neutrophil elastase (NE) TTPLTSQ ELNE_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Neutrophil elastase (NE) DTT ELANE 2.379 2.036 1.379 2.945
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Pulmonary disease
ICD Disease Classification 1B10-1F85
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Neutrophil elastase (NE) DTT ELANE 2.35E-01 -0.55 -0.82
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2358).