Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMKGQF0)

Drug Name
Suvodirsen Drug Info
Synonyms WVE-210201
Indication
Disease Entry ICD 11 Status REF
Duchenne dystrophy 8C70 Phase 2/3 [1]
Cross-matching ID
TTD Drug ID
DMKGQF0

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dystrophin messenger RNA (DMD mRNA) TTWLFXU DMD_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Dystrophin messenger RNA (DMD mRNA) DTT DMD 6.356 5.446 5.459 5.326
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Duchenne dystrophy
ICD Disease Classification 8C70
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Dystrophin messenger RNA (DMD mRNA) DTT DMD 1.15E-07 -1.07 -2.94
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT03907072) Efficacy and Safety Study of WVE-210201 (Suvodirsen) With Open-label Extension in Ambulatory Patients With Duchenne Muscular Dystrophy (DYSTANCE 51). U.S. National Institutes of Health.
2 Advances in oligonucleotide drug delivery. Nat Rev Drug Discov. 2020 Oct;19(10):673-694.