Details of the Drug

General Information of Drug (ID: DMKGQF0)

Drug Name
Suvodirsen
Synonyms WVE-210201
Indication
Disease Entry ICD 11 Status REF
Duchenne dystrophy 8C70 Phase 2/3 [1]
Drug Type
Antisense oligonucleotide
Sequence
UCAAGGAAGAUGGCAUUUCU
Cross-matching ID
TTD ID
D4OZC7

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dystrophin messenger RNA (DMD mRNA) TTWLFXU DMD_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Duchenne dystrophy
ICD Disease Classification 8C70
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Dystrophin messenger RNA (DMD mRNA) DTT DMD 1.15E-07 -1.07 -2.94
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 ClinicalTrials.gov (NCT03907072) Efficacy and Safety Study of WVE-210201 (Suvodirsen) With Open-label Extension in Ambulatory Patients With Duchenne Muscular Dystrophy (DYSTANCE 51). U.S. National Institutes of Health.
2 Advances in oligonucleotide drug delivery. Nat Rev Drug Discov. 2020 Oct;19(10):673-694.