Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMKSFPE)

Drug Name

BMS 275291 Drug Info

Synonyms

D 2163; N-((2S)-2-Mercapto-1-oxo-4-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)butyl)-L-leucyl-N,3-dimethyl-L-valinamide; (2S)-N-[(2S)-3,3-dimethyl-2-(methylamino)butanoyl]-4-methyl-2-[[(2S)-2-sulfanyl-4-(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)butanoyl]amino]pentanamide

Indication

Disease Entry	ICD 11	Status	REF
Kaposi sarcoma	2B57	Discontinued in Phase 3	[1]
Non-small-cell lung cancer	2C25.Y	Discontinued in Phase 3	[1]
Prostate cancer	2C82.0	Discontinued in Phase 3	[1]

Therapeutic Class

Anticancer Agents

Cross-matching ID

PubChem CID: 148203
TTD Drug ID: DMKSFPE

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Matrix metalloproteinase-1 (MMP-1)	TTMX39J	MMP1_HUMAN	Inhibitor	[1]
Matrix metalloproteinase-2 (MMP-2)	TTLM12X	MMP2_HUMAN	Inhibitor	[1]
Matrix metalloproteinase-7 (MMP-7)	TTMTWOS	MMP7_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Matrix metalloproteinase-1 (MMP-1)	DTT	MMP1	2.263	0.263	2.433	5.403
Matrix metalloproteinase-7 (MMP-7)	DTT	MMP7	5.567	5.479	9.387	2.766
Matrix metalloproteinase-2 (MMP-2)	DTT	MMP2	5.766	9.299	8.247	8.608

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Kaposi sarcoma

ICD Disease Classification

2B57

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Matrix metalloproteinase-1 (MMP-1)	DTT	MMP1	7.25E-65	0.99	3.23
Matrix metalloproteinase-7 (MMP-7)	DTT	MMP7	4.87E-01	-0.2	-0.57
Matrix metalloproteinase-2 (MMP-2)	DTT	MMP2	3.48E-16	-0.11	-0.43

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Phase 1/2 trial of BMS-275291 in patients with human immunodeficiency virus-related Kaposi sarcoma: a multicenter trial of the AIDS Malignancy Consortium. Cancer. 2008 Mar 1;112(5):1083-8.