Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMKX5R8)

Drug Name	PMID29130358-Compound-Figure16(9a) Drug Info
Cross-matching ID	PubChem CID 58107501 TTD Drug ID DMKX5R8

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Matrix metalloproteinase-13 (MMP-13)	TTHY57M	MMP13_HUMAN	Inhibitor	[1]
Matrix metalloproteinase-2 (MMP-2)	TTLM12X	MMP2_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Matrix metalloproteinase-2 (MMP-2)	DTT	MMP2	5.766	9.299	8.247	8.608
Matrix metalloproteinase-13 (MMP-13)	DTT	MMP13	1.263	4.603	2.138	1.963

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Matrix metalloproteinase-2 (MMP-2)	DTT	MMP2	1.29E-01	0.25	0.83
Matrix metalloproteinase-13 (MMP-13)	DTT	MMP13	1.25E-03	0.76	1.3

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46.