Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DML3AZG)

• Drug Name: McN-A-343 Drug Info
• Synonyms: McN-A-343; 55-45-8; MCN A-343 chloride; McN-A 343; MCN A-343; UNII-CW55R761RE; (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium chloride; CW55R761RE; A 343; 4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; 2-Butyn-1-aminium, 4-((((3-chlorophenyl)amino)carbonyl)oxy)-N,N,N-trimethyl-, chloride; Carbanilic acid, m-chloro-, ester with (4-hydroxy-2-butynyl)trimethylammonium chloride; Butyl-1-aminium, 4-((((3-chlorophenyl)amino)carbonyl)oxy)-N,N,N-trimethyl-, chloride

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5926
  CAS Number: CAS 55-45-8
  TTD Drug ID: DML3AZG

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor (CHRM)	TTOXS3C	NOUNIPROTAC	Agonist	[2]
Muscarinic acetylcholine receptor M3 (CHRM3)	TTQ13Z5	ACM3_HUMAN	Agonist	[3]

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Muscarinic acetylcholine receptor M3 (CHRM3)	DTT	CHRM3	4.61E-07	-0.59	-0.73

References

• [1] International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands. Pharmacol Rev. 2014 Oct;66(4):918-47.
• [2] Pharmacological characterization of the M1 muscarinic receptors expressed in murine fibroblast B82 cells. J Pharmacol Exp Ther. 1989 Feb;248(2):661-70.
• [3] Human muscarinic receptors expressed in A9L and CHO cells: activation by full and partial agonists. Br J Pharmacol. 1995 Mar;114(6):1241-9.