Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DML3OYH)

Drug Name
TriMixDC Drug Info
Synonyms Dendritic cell vaccine (melanoma), Vrije Universiteit Brussel; TriMixDC (melanoma, intrademal), Universite Libre de Bruxelles
Indication
Disease Entry ICD 11 Status REF
Melanoma 2C30 Investigative [1]
Cross-matching ID
TTD Drug ID
DML3OYH

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
CD70 antigen (CD27-L) TTNCIE0 CD70_HUMAN Not Available [1]
TNF related activation protein (CD40LG) TTIJP3Q CD40L_HUMAN Not Available [1]
Toll-like receptor 4 (TLR4) TTISGCA TLR4_HUMAN Not Available [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
CD70 antigen (CD27-L) DTT CD70 5.138 3.35 4.621 2.907
Toll-like receptor 4 (TLR4) DTT TLR4 5.853 5.555 6.158 5.82
TNF related activation protein (CD40LG) DTT CD40LG 3.573 2.406 3.632 3.733
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Melanoma
ICD Disease Classification 2C30
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
TNF related activation protein (CD40LG) DTT CD40LG 8.02E-01 -0.13 -0.7
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Characterization of CD8+ T-cell responses in the peripheral blood and skin injection sites of melanoma patients treated with mRNA electroporated autologous dendritic cells (TriMixDC-MEL). Biomed Res Int. 2013;2013:976383.