Details of the Drug

General Information of Drug (ID: DML3OYH)

Drug Name

TriMixDC

Synonyms

Dendritic cell vaccine (melanoma), Vrije Universiteit Brussel; TriMixDC (melanoma, intrademal), Universite Libre de Bruxelles

Indication

Disease Entry	ICD 11	Status	REF
Melanoma	2C30	Investigative	[1]
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Drug Type

Vaccine

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
CD70 antigen (CD27-L)	TTNCIE0	CD70_HUMAN	Not Available	[1]
TNF related activation protein (CD40LG)	TTIJP3Q	CD40L_HUMAN	Not Available	[1]
Toll-like receptor 4 (TLR4)	TTISGCA	TLR4_HUMAN	Not Available	[1]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Melanoma

ICD Disease Classification

2C30

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
TNF related activation protein (CD40LG)	DTT	CD40LG	8.02E-01	-0.13	-0.7

Molecular Expression Atlas (MEA)

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References

1	Characterization of CD8+ T-cell responses in the peripheral blood and skin injection sites of melanoma patients treated with mRNA electroporated autologous dendritic cells (TriMixDC-MEL). Biomed Res Int. 2013;2013:976383.