Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMLDWCB)

Drug Name
RPR-118723 Drug Info
Synonyms RPR-118723; CHEMBL80649
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
9796571
TTD Drug ID
DMLDWCB

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glutamate receptor AMPA (GRIA) TTAN6JD NOUNIPROTAC Inhibitor [1]
Glutamate receptor AMPA 1 (GRIA1) TTVPQTF GRIA1_HUMAN Inhibitor [1]
Glutamate receptor ionotropic NMDA 1 (NMDAR1) TTLD29N NMDZ1_HUMAN Inhibitor [1]
Glutamate receptor ionotropic NMDA 2A (NMDAR2A) TTKJEMQ NMDE1_HUMAN Inhibitor [1]
Glutamate receptor ionotropic NMDA 2B (NMDAR2B) TTN9D8E NMDE2_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Glutamate receptor AMPA 1 (GRIA1) DTT GRIA1 3.209 3.365 3.194 3.379
Glutamate receptor ionotropic NMDA 2B (NMDAR2B) DTT GRIN2B 4.926 3.921 4.542 5.682
Glutamate receptor ionotropic NMDA 1 (NMDAR1) DTT GRIN1 3.828 2.744 3.392 3.307
Glutamate receptor ionotropic NMDA 2A (NMDAR2A) DTT GRIN2A 5 5.446 5.459 3.35
Glutamate receptor AMPA (GRIA) DTT GRIA 3.07 2.907 2.945 3.485
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Glutamate receptor AMPA 1 (GRIA1) DTT GRIA1 1.46E-06 -0.63 -0.78
Glutamate receptor AMPA (GRIA) DTT NO-GeName 1.79E-04 -0.69 -0.58
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Indeno[1,2-b]pyrazin-2,3-diones: a new class of antagonists at the glycine site of the NMDA receptor with potent in vivo activity. J Med Chem. 2000 Jun 15;43(12):2371-81.