General Information of Drug (ID: DMLV1ET)

Drug Name
BIIB074 Drug Info
Synonyms CNV1014082; BC600719; HY-12796; B5927; (5R)-5-(4-[2-
Indication
Disease Entry ICD 11 Status REF
Bipolar disorder 6A60 Phase 2 [1]
Lumbosacral radiculopathy 8B93.Y Phase 2 [2]
Trigeminal neuralgia 8B82.0 Phase 2 [2]
Cross-matching ID
PubChem CID
16046068
CAS Number
CAS 934240-30-9
TTD Drug ID
DMLV1ET
VARIDT Drug ID
DR01050

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated sodium channel alpha Nav1.7 (SCN9A) TT4G2JS SCN9A_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DTT SCN9A 3.787 1.926 0.263 0.263
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Bipolar disorder
ICD Disease Classification 6A60
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Voltage-gated sodium channel alpha Nav1.7 (SCN9A) DTT SCN9A 1.42E-03 -0.12 -0.36
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027679)
2 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.