Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMM0HAE)

Drug Name

DSC-127 Drug Info

Synonyms

aclerastide; UNII-YYD6UT8T47; YYD6UT8T47; Aclerastide [INN]; DSC-127; Norleu3-a(1-7); Asp-arg-nle-tyr-ile-his-pro; DSC127; USB-001; 227803-63-6; 1-7-Angiotensin II, 3-L-norleucine-5-L-isoleucine

Indication

Disease Entry	ICD 11	Status	REF
Diabetic foot ulcer	BD54	Phase 3	[1]

Cross-matching ID

PubChem CID: 9811551
CAS Number: CAS 227803-63-6
TTD Drug ID: DMM0HAE

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Proto-oncogene Mas (MAS)	TTOISYB	MAS_HUMAN	Agonist	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Proto-oncogene Mas (MAS)	DTT	MAS1	6.09	4.358	6.274	6.248

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Diabetic foot ulcer

ICD Disease Classification

BD54

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Proto-oncogene Mas (MAS)	DTT	MAS1	2.91E-75	-0.43	-1.38

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8300).
2	New therapeutic pathways in the RAS. J Renin Angiotensin Aldosterone Syst. 2012 Dec;13(4):505-8.