Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMM2NSK)

Drug Name
Adenosine Drug Info
Synonyms
Adenosine, homopolymer; Adenine 9-beta-D-arabinofuranoside; Adenine-9-beta-D-ribofuranoside; Beta-D-Ribofuranoside, adenine-9; EA6C60C2-6AFB-4264-A2F0-541373DB950E; (2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; 4-Aminopyrazolo[3,4-d]pyrimidine ribonucleoside; 6-Amino-9-.beta.-ribofuranosyl-9H-purine; 6-Amino-9-beta-D-ribofuranosyl-9H-purine; 6-Amino-9beta-D-ribofuranosyl-9H-purine; 9-(beta-D-Arabinofuranosyl)adenine; 9-beta-D-Ribofuranosidoadenine; 9-beta-D-Ribofuranosyl-9H-purin-6-amine; 9-beta-D-Ribofuranosyladenine; 9beta-D-Ribofuranosyladenine
Indication
Disease Entry ICD 11 Status REF
Paroxysmal supraventricular tachycardia BC81.Z Approved [1]
Therapeutic Class
Antiarrhythmic Agents
Cross-matching ID
PubChem CID
60961
ChEBI ID
CHEBI:16335
CAS Number
CAS 5536-17-4
TTD Drug ID
DMM2NSK
VARIDT Drug ID
DR00904
INTEDE Drug ID
DR0046
ACDINA Drug ID
D00809

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adenosine A2b receptor (ADORA2B) TTNE7KG AA2BR_HUMAN Modulator [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID Highest Status REF
Equilibrative nucleoside transporter 1 (SLC29A1) DTXD1TQ S29A1_HUMAN Approved [3]
Multidrug resistance-associated protein 5 (ABCC5) DTYVM24 MRP5_HUMAN Approved [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Sulfotransferase 1A1 (SULT1A1) DEYWLRK ST1A1_HUMAN Approved [5]
Adenosine aminohydrolase (ADA) DEDQHBV ADA_HUMAN Approved [6]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Adenosine A2b receptor (ADORA2B) DTT ADORA2B 4.853 6.925 4.536 5.409
Multidrug resistance-associated protein 5 (ABCC5) DTP MRP5 7.631 8.055 7.961 7.695
Equilibrative nucleoside transporter 1 (SLC29A1) DTP ENT1 6.521 5.997 5.97 5.897
Sulfotransferase 1A1 (SULT1A1) DME SULT1A1 9.814 9.348 7.196 10.468
Adenosine aminohydrolase (ADA) DME ADA 5.837 5.295 4.706 7.628
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Paroxysmal supraventricular tachycardia
ICD Disease Classification BC81.Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Multidrug resistance-associated protein 5 (ABCC5) DTP MRP5 9.31E-01 3.03E-02 1.15E-01
Equilibrative nucleoside transporter 1 (SLC29A1) DTP ENT1 7.28E-01 1.90E-01 3.49E-01
Sulfotransferase 1A1 (SULT1A1) DME SULT1A1 6.22E-02 1.64E-01 5.58E-01
Adenosine aminohydrolase (ADA) DME ADA 4.76E-01 -2.60E-02 -7.82E-02
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2844).
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3 Nitric oxide reduces adenosine transporter ENT1 gene (SLC29A1) promoter activity in human fetal endothelium from gestational diabetes. J Cell Physiol. 2006 Aug;208(2):451-60.
4 Role of MRP4 and MRP5 in biology and chemotherapy. AAPS PharmSci. 2002;4(3):E14.
5 Regulation of sulfate assimilation in plants: 7. Cysteine inactivation of adenosine 5'-phosphosulfate sulfotransferase in Lemna minor L. Plant Physiol. 1978 Mar;61(3):342-7.
6 A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans. Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15676-81.