Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMM41AQ)

Drug Name

6-Chloro-2-piperazin-1-yl-quinoline Drug Info

Synonyms

6-chloro-2-piperazin-1-yl-quinoline; 78060-46-5; 6-Chloro-2-(piperazin-1-yl)quinoline; 6-chloro-2-piperazin-1-ylquinoline; 6-chloro-2-(1-piperazinyl)quinoline; CHEMBL290537; AC1Q3JZ5; 2-Piperazino-6-chloroquinoline; SCHEMBL4182196; CTK5E5334; DTXSID60437575; GSFXEINORRSYJW-UHFFFAOYSA-N; ZINC2527450; 3506AJ; BDBM50090216; AKOS022401900; AB19847; 6-chloranyl-2-piperazin-1-yl-quinoline; Quinoline,6-chloro-2-(1-piperazinyl)-; AJ-83656; AX8029614; KB-248323; DB-075405; FT-0719429; Z-5014

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10264015
CAS Number: CAS 78060-46-5
TTD Drug ID: DMM41AQ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Serotonin transporter (SERT)	DTT	SLC6A4	6.278	5.469	6.075	6.966

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Serotonin transporter (SERT)	DTT	SLC6A4	8.76E-01	7.18E-05	6.19E-04

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 1. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1559-62.