Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMMAQJ7)

Drug Name
CAR-T cells targeting Mesothelin Drug Info
Indication
Disease Entry ICD 11 Status REF
Cervical cancer 2C77.0 Phase 1/2 [1]
Lung cancer 2C25.0 Phase 1/2 [2]
Cross-matching ID
TTD Drug ID
DMMAQJ7

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Mesothelin (MSLN) TT4RXME MSLN_HUMAN CAR-T-Cell-Therapy [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Mesothelin (MSLN) DTT MSLN -0.515 2.233 -0.152 0
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Cervical cancer
ICD Disease Classification 2C77.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Mesothelin (MSLN) DTT MSLN 2.86E-20 3.98 6.12
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT03356795) Intervention of CAR-T Against Cervical Cancer
2 ClinicalTrials.gov (NCT03356808) Antigen-specific T Cells Against Lung Cancer