Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMME8LH)

Drug Name
Alitretinoin Drug Info
Indication
Disease Entry ICD 11 Status REF
Kaposi sarcoma 2B57 Approved [1] , [2]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
449171
ChEBI ID
CHEBI:50648
CAS Number
CAS 5300-03-8
TTD Drug ID
DMME8LH
VARIDT Drug ID
DR00315
INTEDE Drug ID
DR2501

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Retinoic acid receptor beta (RARB) TTISP28 RARB_HUMAN Agonist [3]
Retinoic acid receptor gamma (RARG) TT1Q3IE RARG_HUMAN Modulator [3] , [4] , [5]
Retinoic acid receptor RXR-alpha (RXRA) TT6PEUO RXRA_HUMAN Agonist [3]
Retinoic acid receptor RXR-beta (RXRB) TTKLV96 RXRB_HUMAN Agonist [3]
Retinoic acid receptor RXR-gamma (RXRG) TTH029C RXRG_HUMAN Agonist [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Approved [6]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Retinoic acid receptor beta (RARB) DTT RARB 4.498 5.661 6.267 4.591
Retinoic acid receptor RXR-gamma (RXRG) DTT RXRG 5.536 5.618 5.347 6.259
Retinoic acid receptor gamma (RARG) DTT RARG 4.315 4.573 4.104 4.878
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 11.692 6.58 4.984 9.089
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Kaposi sarcoma
ICD Disease Classification 2B57
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Retinoic acid receptor beta (RARB) DTT RARB 9.92E-02 -0.05 -0.21
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 1.04E-02 6.29E-02 3.54E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2645).
2 Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
3 Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):30-4.
4 Targacept active conformation search: a new method for predicting the conformation of a ligand bound to its protein target. J Med Chem. 2004 Dec 30;47(27):6831-9.
5 Alitretinoin: a comprehensive review. Expert Opin Investig Drugs. 2008 Mar;17(3):437-43.
6 Alitretinoin in dermatology-an update. Indian J Dermatol. 2015 Sep-Oct;60(5):520.