Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMMIR1K)

Drug Name

GSK184072 Drug Info

Synonyms

Flutimide; 162666-34-4; AC1O5YLM; AKOS027326745; (5Z)-1-hydroxy-3-isobutyl-5-(2-methylpropylidene)pyrazine-2,6-dione; 2,6-(1H,3H)-Pyrazinedione, 1-hydroxy-5-(2-methylpropyl)-3-(2-methylpropylidene)-, (Z)-; 2,6-(1H,3H)-Pyrazinedione, 1-hydroxy-5-(2-methylpropyl)-3-(2-methylpropylidene)-, (3Z)-; (5Z)-1-hydroxy-3-(2-methylpropyl)-5-(2-methylpropylidene)pyrazine-2,6-dione

Indication

Disease Entry	ICD 11	Status	REF
Colon cancer	2B90.Z	Discontinued in Phase 2	[1]
Hematologic tumour	2B33.Y	Discontinued in Phase 2	[1]
Type-2 diabetes	5A11	Discontinued in Phase 2	[1]

Cross-matching ID

PubChem CID: 6443207
CAS Number: CAS 162666-34-4
TTD Drug ID: DMMIR1K

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
CAP-dependent endonuclease (CDE)	TTTG60L	NOUNIPROTAC	Inhibitor	[2]
NAD-dependent deacetylase sirtuin-1 (SIRT1)	TTUF2HO	SIR1_HUMAN	Activator	[3]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
NAD-dependent deacetylase sirtuin-1 (SIRT1)	DTT	SIRT1	6.202	6.863	6.331	6.61

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Colon cancer

ICD Disease Classification

2B90.Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
NAD-dependent deacetylase sirtuin-1 (SIRT1)	DTT	SIRT1	7.82E-01	-0.16	-0.27

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024569)
2	Synthesis of natural flutimide and analogous fully substituted pyrazine-2,6-diones, endonuclease inhibitors of influenza virus. J Org Chem. 2001 Aug 10;66(16):5504-16.
3	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).