Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMMO0SU)

Drug Name

Dersimelagon Drug Info

Synonyms

Dersimelagon; 1835256-48-8; Dersimelagon [INN]; Dersimelagon [USAN]; MT-7117; 1CWH5SV4G2; 1-(2-((3S,4R)-1-((3R,4R)-1-Cyclopentyl-3-fluoro-4-(4-methoxyphenyl)pyrrolidine-3-carbonyl)-4-(methoxymethyl)pyrrolidin-3-yl)-5-(trifluoromethyl)phenyl)piperidine-4-carboxylic acid; Dersimelagon [USAN:INN]; UNII-1CWH5SV4G2; DERSIMELAGON [WHO-DD]; CHEMBL4802160; SCHEMBL18686769; MUNWOYRHJPWQNE-GMFUQMJFSA-N; WHO 10832; AKOS040746751; AC-36942; HY-109114; CS-0077733; 4-PIPERIDINECARBOXYLIC ACID, 1-(2-((3S,4R)-1-(((3R,4R)-1-CYCLOPENTYL-3-FLUORO-4-(4-METHOXYPHENYL)-3-PYRROLIDINYL)CARBONYL)-4-(METHOXYMETHYL)-3-PYRROLIDINYL)-5- (TRIFLUOROMETHYL)PHENYL)-

Indication

Disease Entry	ICD 11	Status	REF
Erythropoietic protoporphyria	5C58.12	Phase 3	[1]

Cross-matching ID

PubChem CID: 126736894
TTD Drug ID: DMMO0SU

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Melanocortin receptor 1 (MC1R)	TT0MV2T	MSHR_HUMAN	Agonist	[2]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Melanocortin receptor 1 (MC1R)	DTT	MC1R	5.907	5.989	5.883	6.877

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Erythropoietic protoporphyria

ICD Disease Classification

5C58.12

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Melanocortin receptor 1 (MC1R)	DTT	MC1R	1.44E-06	0.41	2.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT04402489) A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Efficacy, Safety, and Tolerability of MT-7117 in Adults and Adolescents With Erythropoietic Protoporphyria or X-Linked Protoporphyria. U.S.National Institutes of Health.
2	Dersimelagon, a novel oral melanocortin 1 receptor agonist, demonstrates disease-modifying effects in preclinical models of systemic sclerosis. Arthritis Res Ther. 2022 Sep 1;24(1):210.