Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMN0Q71)

Drug Name

Sulfamic acid chroman-2-ylmethyl ester Drug Info

Synonyms

CHEMBL180475; 835894-63-8; Sulfamic acid, (3,4-dihydro-2H-1-benzopyran-2-yl)methyl ester; Sulfamic acid chroman-2-ylmethyl ester; SCHEMBL5274616; CTK3D1605; DTXSID80463432; BDBM50163317; (3,4-dihydro-2H-chromen-2-yl)methyl sulfamate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11356944
CAS Number: CAS 835894-63-8
TTD Drug ID: DMN0Q71

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform. J Med Chem. 2005 Mar 24;48(6):1941-7.