Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMNI0KO)

Drug Name
Denosumab Drug Info
Synonyms Denosumab (USAN); Denosumab (genetical recombination); Prolia (TN); Denosumab (genetical recombination) (JAN)
Indication
Disease Entry ICD 11 Status REF
Drug-induced osteoporosis Approved [1]
Osteoporosis FB83.0 Approved [2]
Postmenopausal osteoporosis FB83.11 Approved [3]
Prostate cancer 2C82.0 Phase 3 [3]
Rheumatoid arthritis FA20 Phase 2 [3]
Cross-matching ID
TTD Drug ID
DMNI0KO

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Osteoclast differentiation factor (ODF) TT9E8HR TNF11_HUMAN Not Available [4]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Osteoclast differentiation factor (ODF) DTT TNFSF11 3.733 2.868 3.807 3.53
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 15 Disease of the musculoskeletal system/connective tissue
Disease Class ICD-11: FA20 Rheumatoid arthritis
The Studied Tissue Synovial tissue
The Studied Disease Rheumatoid arthritis [ICD-11:FA20]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Osteoclast differentiation factor (ODF) DTT TNFSF11 1.51E-02 0.53 1.49
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Hormone-Related and Drug-Induced Osteoporosis: A Cellular and Molecular Overview. Int J Mol Sci. 2023 Mar 18;24(6):5814.
2 Denosumab and incidence of type 2 diabetes among adults with osteoporosis: population based cohort study. BMJ. 2023 Apr 18;381:e073435.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6886).
4 Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.