Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMNMEPB)

Drug Name

2-Naphthalen-2-ylmethyl-4,5-dihydro-1H-imidazole Drug Info

Synonyms

CHEMBL441948; 2-Naphthalen-2-ylmethyl-4,5-dihydro-1H-imidazole; DSSTox_RID_82756; DSSTox_CID_28423; DSSTox_GSID_48449; 2-(naphthalen-2-ylmethyl)-4,5-dihydro-1H-imidazole; CAS-835-31-4; SMR000054538; Lopac-N-5504; AC1LD21I; Lopac0_000828; CBDivE_007782; MLS000104605; SCHEMBL953099; cid_610682; DTXSID3048449; VIXRKFBKWOHVBR-UHFFFAOYSA-N; MolPort-001-896-776; HMS2287I17; ZINC2472262; CCG-2426; Tox21_113058; Tox21_113645; BDBM50057120; MCULE-4581148654; NCGC00015743-03; NCGC00015743-02; NCGC00015743-01; BAS 00364529; AB00076191-01

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 610682
TTD Drug ID: DMNMEPB

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Serotonin transporter (SERT)	DTT	SLC6A4	6.278	5.469	6.075	6.966

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Serotonin transporter (SERT)	DTT	SLC6A4	8.76E-01	7.18E-05	6.19E-04

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Structure-activity studies for a novel series of N-(arylethyl)-N-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-N-methylamine s possessing dual 5-HT upt... J Med Chem. 1997 Mar 28;40(7):1049-62.