General Information of Drug (ID: DMNMEPB)

Drug Name
2-Naphthalen-2-ylmethyl-4,5-dihydro-1H-imidazole Drug Info
Synonyms
CHEMBL441948; 2-Naphthalen-2-ylmethyl-4,5-dihydro-1H-imidazole; DSSTox_RID_82756; DSSTox_CID_28423; DSSTox_GSID_48449; 2-(naphthalen-2-ylmethyl)-4,5-dihydro-1H-imidazole; CAS-835-31-4; SMR000054538; Lopac-N-5504; AC1LD21I; Lopac0_000828; CBDivE_007782; MLS000104605; SCHEMBL953099; cid_610682; DTXSID3048449; VIXRKFBKWOHVBR-UHFFFAOYSA-N; MolPort-001-896-776; HMS2287I17; ZINC2472262; CCG-2426; Tox21_113058; Tox21_113645; BDBM50057120; MCULE-4581148654; NCGC00015743-03; NCGC00015743-02; NCGC00015743-01; BAS 00364529; AB00076191-01
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
610682
TTD Drug ID
DMNMEPB

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Serotonin transporter (SERT) TT3ROYC SC6A4_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Serotonin transporter (SERT) DTT SLC6A4 6.278 5.469 6.075 6.966
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Serotonin transporter (SERT) DTT SLC6A4 8.76E-01 7.18E-05 6.19E-04
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Structure-activity studies for a novel series of N-(arylethyl)-N-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-N-methylamine s possessing dual 5-HT upt... J Med Chem. 1997 Mar 28;40(7):1049-62.