Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMNPKZ6)

Drug Name

3-[(Z)-2-phenylvinyl]pyridine Drug Info

Synonyms

pyridine,3-(2-phenylethenyl)-,(z)-; 3-[(Z)-2-phenylethenyl]pyridine; 5097-90-5; Styrylpyridine 16; 3-[(Z)-2-phenylvinyl]pyridine; cis-3-styrylpyridine; 3-[(Z)-Styryl]pyridine; AC1O70HN; BDBM8900; CHEMBL206125; ZINC13684559; AKOS024262946

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6540056
TTD Drug ID: DMNPKZ6

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Steroid 11-beta-hydroxylase (CYP11B1)	TTIQUX7	C11B1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	5.647	4.954	5.678	6.194

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	4.31E-04	-0.03	-0.13

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B... J Med Chem. 2006 Apr 6;49(7):2222-31.