Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMNV1ST)

Drug Name

C-10068 Drug Info

Synonyms

Deuterated sigma-1 agonists (epilepsy/brain injury/neuropathic pain); Deuterated sigma-1 agonists (epilepsy/brain injury/neuropathic pain), CoNCERT/Walter Reed Army Institute

Indication

Disease Entry	ICD 11	Status	REF
Brain injury	NA07.Z	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMNV1ST

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Opioid receptor sigma 1 (OPRS1)	TT5TPI6	SGMR1_HUMAN	Agonist	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Opioid receptor sigma 1 (OPRS1)	DTT	SIGMAR1	7.092	5.716	5.411	6.434

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Brain injury

ICD Disease Classification

NA07.Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Opioid receptor sigma 1 (OPRS1)	DTT	SIGMAR1	2.77E-06	-0.12	-0.62

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.