Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMNYQGV)

Drug Name

4-(4-chlorobenzyl)-2-methylphthalazin-1(2H)-one Drug Info

Synonyms

CHEMBL67457; 4-(4-chlorobenzyl)-2-methylphthalazin-1(2H)-one; 4-[(4-chlorophenyl)methyl]-2-methyl-phthalazin-1-one; BDBM50131411; 4-(4-Chloro-benzyl)-2-methyl-2H-phthalazin-1-one; 2-Methyl-4-(4-chlorobenzyl)-1,2-dihydrophthalazine-1-one; 1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-methyl-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11522042
TTD Drug ID: DMNYQGV

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-1A (ADRA1A)	TTNGILX	ADA1A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1D (ADRA1D)	TT34BHT	ADA1D_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adrenergic receptor alpha-1A (ADRA1A)	DTT	ADRA1A	3.154	3.853	4.129	2.963

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor alpha-1A (ADRA1A)	DTT	ADRA1A	9.43E-01	-0.03	-0.25

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Vasorelaxant activity of phthalazinones and related compounds. Bioorg Med Chem Lett. 2006 May 15;16(10):2786-90.