Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMNZYWR)

Drug Name

1-(3,3-Dimethyl-2-oxo-butyl)-1H-indole-2,3-dione Drug Info

Synonyms

1-(3,3-dimethyl-2-oxobutyl)-1H-indole-2,3-dione; 1-(3,3-dimethyl-2-oxobutyl)indole-2,3-dione; 214417-82-0; CHEMBL82686; AC1MU297; CTK7F3764; MolPort-003-013-041; ZINC3037941; ALBB-006420; STK506481; AKOS001570268; MCULE-7778783398; CCG-198354; TR-059060; SR-01000550574; 1-(2-Oxo-3,3-dimethylbutyl)-2,3-indolinedione

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3659236
TTD Drug ID: DMNZYWR

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neutrophil elastase (NE)	TTPLTSQ	ELNE_HUMAN	Inhibitor	[1]
Plasminogen (PLG)	TTP86E2	PLMN_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Neutrophil elastase (NE)	DTT	ELANE	2.379	2.036	1.379	2.945
Plasminogen (PLG)	DTT	PLG	11.754	0.848	8.393	2.138

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Plasminogen (PLG)	DTT	PLG	8.61E-01	-0.01	-0.09

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Parallel synthesis of isatin-based serine protease inhibitors. Bioorg Med Chem Lett. 2000 Nov 20;10(22):2501-4.