Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMO4E9U)

Drug Name

N-isobutyl-2-oxo-2H-chromene-3-carboxamide Drug Info

Synonyms

N-isobutyl-2-oxo-2H-chromene-3-carboxamide; AC1LGLK5; 3-carboxamido coumarin, 3; Oprea1_019533; CHEMBL512883; BDBM29154; MolPort-002-807-315; HMS1722A09; ZINC341401; AKOS001056674; MCULE-2251500223; 1846-84-0; ST50811140; N-(2-methylpropyl)-2-oxochromene-3-carboxamide; SR-01000051779; AG-670/14532137; N-(2-methylpropyl)(2-oxochromen-3-yl)carboxamide; SR-01000051779-1; N-(2-methylpropyl)-2-oxo-2H-chromene-3-carboxamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 823440
TTD Drug ID: DMO4E9U

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Monoamine oxidase type B (MAO-B)	DTT	MAOB	9.367	6.907	8.237	8.409

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Monoamine oxidase type B (MAO-B)	DTT	MAOB	2.65E-02	1.12E-02	0.07

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins. J Med Chem. 2009 Apr 9;52(7):1935-42.