Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMOBLGK)

• Drug Name: Tromethamine Drug Info
• Synonyms: Trometamol; 77-86-1; TROMETHAMINE; Tris; Tris(Hydroxymethyl)aminomethane; Tham; Trisamine; 2-Amino-2-(hydroxymethyl)-1,3-propanediol; Trizma; Tris buffer; Tris base; Tromethane; Trisaminol; Talatrol; Trispuffer; Trisamin; Pehanorm; Tutofusin tris; Tris-steril; Apiroserum Tham; Addex-tham; Tris-base; Tris, free base; Trimethylolaminomethane; 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-; Tris Amino; Aminotrimethylolmethane; Aminotris(hydroxymethyl)methane; THAM-E; Tris (buffering agent); Tris(Hydroxymethyl)Aminomethane

Indication

Disease Entry	ICD 11	Status	REF
Acidosis	5C73	Approved	[1]

• Cross-matching ID:
  PubChem CID: 6503
  ChEBI ID: CHEBI:9754
  CAS Number: CAS 77-86-1
  TTD Drug ID: DMOBLGK
  ACDINA Drug ID: D01507

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
S-adenosylmethionine decarboxylase proenzyme (AMD1)	TTBFROQ	DCAM_HUMAN	Inhibitor	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
S-adenosylmethionine decarboxylase proenzyme (AMD1)	DTT	AMD1	6.747	6.763	7.033	6.593

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Acidosis
• ICD Disease Classification: 5C73

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
S-adenosylmethionine decarboxylase proenzyme (AMD1)	DTT	AMD1	4.41E-05	0.37	0.61

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7328).
• [2] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.