Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMOFG4M)

Drug Name

2,3,4,5-Tetrahydro-benzo[f][1,4]oxazepine Drug Info

Synonyms

17775-01-8; 2,3,4,5-Tetrahydrobenzo[f][1,4]oxazepine; 2,3,4,5-tetrahydro-1,4-benzoxazepine; 2,3,4,5-Tetrahydro-benzo[f][1,4]oxazepine; CHEMBL118420; 1,4-Benzoxazepine, 2,3,4,5-tetrahydro-; 2.3.4.5-tetrahydro-benzo[f][1,4]oxazepine; 1,4-Benzoxazepine, 2,3,4,5-tetrahydro-, hydrochloride; AC1Q1IB5; AC1Q1IB6; SCHEMBL400964; CTK4D6590; DTXSID90619367; HDVHFHONOKCUHQ-UHFFFAOYSA-N; MolPort-001-792-633; KS-00000I8M; ALBB-011885; CT-115; BDBM50052890; ZINC11802711; ANW-65610; STK897763; AKOS005173482; MCULE-4987146186; CS-W007152; BS-12101

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 21882775
CAS Number: CAS 17775-01-8
TTD Drug ID: DMOFG4M

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-2A (ADRA2A)	TTWG9A4	ADA2A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2B (ADRA2B)	TTWM4TY	ADA2B_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-2C (ADRA2C)	TT2NUT5	ADA2C_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	5.013	2.379	5.594	2.07

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor alpha-2C (ADRA2C)	DTT	ADRA2C	1.76E-01	-0.06	-0.28

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46.