Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMOFTRE)

• Drug Name: Cizolirtine Drug Info
• Synonyms: Cizolirtine [INN]; N,N-dimethyl-2-[(2-methylpyrazol-3-yl)-phenylmethoxy]ethanamine; N,N-dimethyl-2-[(R)-(2-methylpyrazol-3-yl)-phenylmethoxy]ethanamine

Indication

Disease Entry	ICD 11	Status	REF
Neuropathic pain	8E43.0	Phase 2	[1]

• Therapeutic Class: Analgesics
• Cross-matching ID:
  PubChem CID: 132412
  CAS Number: CAS 142155-43-9
  TTD Drug ID: DMOFTRE

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calcitonin gene-related peptide 1 (CALCA)	TTVSFJW	CALCA_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Calcitonin gene-related peptide 1 (CALCA)	DTT	CALCA	5.221	2.818	4.501	4.647

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Neuropathic pain
• ICD Disease Classification: 8E43.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Calcitonin gene-related peptide 1 (CALCA)	DTT	CALCA	1.80E-07	-0.32	-0.62

References

• [1] Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.