Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMOMXP7)

Drug Name

TROPOLONE Drug Info

Synonyms

Tropolone; 533-75-5; 2-Hydroxycyclohepta-2,4,6-trienone; Purpurocatechol; 2-Hydroxy-2,4,6-cycloheptatrien-1-one; 2,4,6-Cycloheptatrien-1-one, 2-hydroxy-; 2-hydroxycyclohepta-2,4,6-trien-1-one; 2-Hydroxytropone; 2-Hydroxy-2,4,6-cycloheptatrienone; UNII-7L6DL16P1T; Tropolone, 98%; CCRIS 6609; NSC89303; EINECS 208-577-2; NSC 89303; BRN 1904978; CHEMBL121188; 7L6DL16P1T; CHEBI:79966; MDYOLVRUBBJPFM-UHFFFAOYSA-N; MFCD00004158; Tropomyosins; 0TR; PubChem6330; NCIMech_000829; AC1L1VY5; DSSTox_RID_83491; DSSTox_CID_29376; DSSTox_GSID_49416

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10789
ChEBI ID: CHEBI:79966
CAS Number: CAS 533-75-5
TTD Drug ID: DMOMXP7

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tyrosinase (TYR)	TTULVH8	TYRO_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tyrosinase (TYR)	DTT	TYR	5.959	5.711	5.973	4.912

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tyrosinase (TYR)	DTT	TYR	6.68E-04	2.54	1.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Discovery of 4-functionalized phenyl-O-beta-D-glycosides as a new class of mushroom tyrosinase inhibitors. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6157-60.