Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMOVE31)

Drug Name
PRT-064445 Drug Info
Synonyms Anticoagulant antidote (bleeding), Portola; Factor Xa inhibitor antidote (bleeding), Portola
Indication
Disease Entry ICD 11 Status REF
Bleeding disorder GA20-GA21 Investigative [1]
Cross-matching ID
TTD Drug ID
DMOVE31

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Coagulation factor Xa (F10) TTCIHJA FA10_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Coagulation factor Xa (F10) DTT F10 7.763 4.672 3.248 4.609
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Bleeding disorder
ICD Disease Classification GA20-GA21
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Coagulation factor Xa (F10) DTT F10 4.84E-02 -0.28 -0.9
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Semuloparin for the prevention of venous thromboembolic events in cancer patients. Drugs Today (Barc). 2012 Jul;48(7):451-7.