Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMOZAM6)

Drug Name

1-(4-Aminobenzyl)-1H-imidazole Drug Info

Synonyms

56643-85-7; 4-Imidazol-1-ylmethylphenylamine; 4-(1H-imidazol-1-ylmethyl)aniline; 4-((1H-imidazol-1-yl)methyl)aniline; 4-(imidazol-1-ylmethyl)aniline; 4-[(1-Imidazolyl)methyl]aniline; 4-Imidazol-1-ylmethyl-phenylamine; 4-[(1H-Imidazol-1-yl)methyl]aniline; 1-(4-Aminobenzyl)imidazole; CHEMBL598389; 4-(imidazolylmethyl)phenylamine; Benzenamine, 4-(1H-imidazol-1-ylmethyl)-; 1-(4-Aminobenzyl)-1H-imidazole; BAS 06504682; AC1LOLP2; SCHEMBL77025; AC1Q520P; CTK5A5496; DTXSID40361425; 4-(imidazol-1-yl)methyl-aniline

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 1265319
CAS Number: CAS 56643-85-7
TTD Drug ID: DMOZAM6

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Steroid 11-beta-hydroxylase (CYP11B1)	TTIQUX7	C11B1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	5.647	4.954	5.678	6.194

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	4.31E-04	-0.03	-0.13

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25.