Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMP4RO3)

Drug Name
5-(phenylethynyl)pyrimidine Drug Info
Synonyms
5-(phenylethynyl)pyrimidine; 71418-88-7; CHEMBL486244; 5-(2-phenylethynyl)pyrimidine; 5-phenylethynylpyrimidine; SCHEMBL4860070; DTXSID50399052; ZINC198515; AC1N4263; BDBM50243108; AKOS001674343; MCULE-6083144775; FCH1171193; AJ-17844; AX8280340; SR-01000501737; SR-01000501737-1
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
4074142
CAS Number
CAS 71418-88-7
TTD Drug ID
DMP4RO3

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Metabotropic glutamate receptor 5 (mGluR5) TTHS256 GRM5_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Metabotropic glutamate receptor 5 (mGluR5) DTT GRM5 3.621 1.888 3.567 4.318
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Metabotropic glutamate receptor 5 (mGluR5) DTT GRM5 9.81E-07 -0.26 -0.54
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5... Bioorg Med Chem Lett. 2008 Jul 15;18(14):4098-101.