Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTHS256)

DTT Name	Metabotropic glutamate receptor 5 (mGluR5)
Synonyms	MGLUR5; GPRC1E
Gene Name	GRM5
DTT Type	Clinical trial target	[1]
Related Disease	Fragile X chromosome [ICD-11: LD55] Parkinsonism [ICD-11: 8A00]
BioChemical Class	GPCR glutamate
UniProt ID	GRM5_HUMAN
TTD ID	T99347
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAV REQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISS EEEEGLVRCVDGSSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLS DKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGI CIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFL LLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQ HRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCP GYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFD YINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKEN EYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVV FIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYS ALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIM HDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYT TCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTS TVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMG NGGRATMSSSNGKSVTWAQNEKSSRGQHLWQRLSIHINKKENPNQTAVIKPFPKSTESRG LGAGAGAGGSAGGVGATGGAGCAGAGPGGPESPDAGPKALYDVAEAEEHFPAPARPRSPS PISTLSHRAGSASRTDDDVPSLHSEPVARSSSSQGSLMEQISSVVTRFTANISELNSMML STAAPSPGVGAPLCSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPAAGAQAAGDAA RESPAAGPEAAAAKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTL IIRDYTQSSSSL
Function	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.
KEGG Pathway	Calcium signaling pathway (hsa04020 ) Neuroactive ligand-receptor interaction (hsa04080 ) Gap junction (hsa04540 ) Long-term potentiation (hsa04720 ) Retrograde endocannabinoid signaling (hsa04723 ) Glutamatergic synapse (hsa04724 ) Huntington's disease (hsa05016 )
Reactome Pathway	Class C/3 (Metabotropic glutamate/pheromone receptors) (R-HSA-420499 ) G alpha (q) signalling events (R-HSA-416476 )

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This DTT

9 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ADX-48621	DM6GTMD	Parkinson disease	8A00.0	Phase 2/3	[2]
Afq056	DMMHSLC	Fragile X syndrome	LD55	Phase 2/3	[1]
ADX10059	DMGVKHQ	Anxiety disorder	6B00-6B0Z	Phase 2	[3], [4]
RG-7090	DMX8JYN	Fragile X syndrome	LD55	Phase 2	[5]
STX-107	DMLNKX7	Autism spectrum disorder	6A02	Phase 2	[6], [7]
McN3377	DMTCADJ	Fragile X syndrome	LD55	Phase 1/2	[8]
MK-3328	DMW2O5D	Alzheimer disease	8A20	Phase 1	[9]
RG7342	DMIW5NG	Schizophrenia	6A20	Phase 1	[10]
[3H]fenobam	DMBOXA1	Allodynia	MB40.1	Phase 1	[11]
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⏷ Show the Full List of 9 Clinical Trial Drug(s)

68 Patented Agent(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-(substituted ethynyl)quinoline derivative 1	DMOY5EK	N. A.	N. A.	Patented	[12]
2-(substituted ethynyl)quinoline derivative 2	DMPCYSW	N. A.	N. A.	Patented	[12]
2-(substituted ethynyl)quinoline derivative 3	DMMF8A1	N. A.	N. A.	Patented	[12]
2-(substituted ethynyl)quinoline derivative 4	DMTXZUF	N. A.	N. A.	Patented	[12]
6-aryl-imidazopyridine and 6-aryl-triazolopyridine carboxamide analog 1	DMTXGYS	N. A.	N. A.	Patented	[12]
6-aryl-imidazopyridine and 6-aryl-triazolopyridine carboxamide analog 2	DMFKTBM	N. A.	N. A.	Patented	[12]
6-aryl-imidazopyridine and 6-aryl-triazolopyridine carboxamide analog 3	DMXMTLP	N. A.	N. A.	Patented	[12]
Bicarboxylic and tricarboxylic ethynyl derivative 1	DMDK7LQ	N. A.	N. A.	Patented	[12]
Bicarboxylic and tricarboxylic ethynyl derivative 2	DMG9O7D	N. A.	N. A.	Patented	[12]
Bicarboxylic and tricarboxylic ethynyl derivative 3	DM1KVTZ	N. A.	N. A.	Patented	[12]
Bicyclic heteroaryl carboxamide analog 1	DMB5XDM	N. A.	N. A.	Patented	[12]
Bicyclic heteroaryl carboxamide analog 2	DMKT7MD	N. A.	N. A.	Patented	[12]
Bicyclic heteroaryl carboxamide analog 3	DM3QMA0	N. A.	N. A.	Patented	[12]
Central azetidine derivative 1	DM7INA1	N. A.	N. A.	Patented	[12]
Central azetidine derivative 2	DM2BLJ6	N. A.	N. A.	Patented	[12]
Diazepinone derivative 1	DM9YD0Q	Parkinson disease	8A00.0	Patented	[12]
Diazepinone derivative 2	DMLQ7PG	Parkinson disease	8A00.0	Patented	[12]
Diazepinone derivative 3	DMPTZ69	Parkinson disease	8A00.0	Patented	[12]
Diazepinone derivative 4	DM389YD	Parkinson disease	8A00.0	Patented	[12]
Diazepinone derivative 5	DM2U1QH	Parkinson disease	8A00.0	Patented	[12]
Ethynyl compound 1	DMWXKRZ	N. A.	N. A.	Patented	[12]
Ethynyl compound 2	DMJDG37	N. A.	N. A.	Patented	[12]
Ethynyl compound 3	DMD9PZQ	N. A.	N. A.	Patented	[12]
Ethynyl compound 4	DMLDMO8	N. A.	N. A.	Patented	[12]
Ethynyl compound 5	DM53ZPE	N. A.	N. A.	Patented	[12]
Ethynyl compound 6	DMDOEFC	N. A.	N. A.	Patented	[12]
Ethynyl compound 7	DMPUG2M	N. A.	N. A.	Patented	[12]
Heterocyclic derivative 1	DMJ5X46	N. A.	N. A.	Patented	[12]
Heterocyclic derivative 2	DM2QCBF	N. A.	N. A.	Patented	[12]
Heterocyclic derivative 3	DMCD0MS	N. A.	N. A.	Patented	[12]
Imidazopyridine and triazolopyridine compound 1	DMTUS0Y	N. A.	N. A.	Patented	[12]
Imidazopyridine and triazolopyridine compound 2	DMYCLAM	N. A.	N. A.	Patented	[12]
Imidazopyridine and triazolopyridine compound 3	DMWU8VM	N. A.	N. A.	Patented	[12]
Imidazopyridine and triazolopyridine compound 4	DMI1OWK	N. A.	N. A.	Patented	[12]
Imidazo[1,2-a]pyridine derivative 1	DM5NEQ2	N. A.	N. A.	Patented	[12]
N-alkylamide derivative 1	DMXPBL5	N. A.	N. A.	Patented	[12]
N-alkylamide derivative 2	DM568TX	N. A.	N. A.	Patented	[12]
PMID28067079-Compound-95	DMG2PCZ	N. A.	N. A.	Patented	[12]
PMID28067079-Compound-97	DMCUX42	N. A.	N. A.	Patented	[12]
PMID28067079-Compound-98	DMLKP1O	N. A.	N. A.	Patented	[12]
Pyrazolopyrimidine derivative 1	DMHO3NB	N. A.	N. A.	Patented	[12]
Pyrazolopyrimidine derivative 2	DMZEP5X	N. A.	N. A.	Patented	[12]
Pyrazolopyrimidine derivative 3	DMI0J7D	N. A.	N. A.	Patented	[12]
Pyrazolopyrimidine derivative 4	DM7XSHK	N. A.	N. A.	Patented	[12]
Pyrazolopyrimidine derivative 5	DMVUSF3	N. A.	N. A.	Patented	[12]
Pyrazolopyrimidine derivative 6	DMG8V31	N. A.	N. A.	Patented	[12]
Pyridine derivative 12	DM8KBHX	N. A.	N. A.	Patented	[12]
Pyridine derivative 13	DMX8RGH	N. A.	N. A.	Patented	[12]
Pyridine derivative 14	DM7JCM6	N. A.	N. A.	Patented	[12]
Pyridine derivative 15	DMGBR43	N. A.	N. A.	Patented	[12]
Pyridine derivative 16	DMICZLS	N. A.	N. A.	Patented	[12]
Pyridine derivative 17	DMLC5WA	N. A.	N. A.	Patented	[12]
Pyrrolidine derivative 1	DMXALJE	N. A.	N. A.	Patented	[12]
Pyrrolidine derivative 2	DM5WA29	N. A.	N. A.	Patented	[12]
Pyrrolidine derivative 3	DMHM8WJ	N. A.	N. A.	Patented	[12]
Pyrrolidine derivative 4	DMZ2HBL	N. A.	N. A.	Patented	[12]
Pyrrolidine derivative 5	DM5NKXO	N. A.	N. A.	Patented	[12]
Tetra-hydro-oxazolopyridine derivative 1	DM72MDA	N. A.	N. A.	Patented	[12]
Tetra-hydro-oxazolopyridine derivative 2	DMP65Z4	N. A.	N. A.	Patented	[12]
Tetra-hydro-oxazolopyridine derivative 3	DMQYKT2	N. A.	N. A.	Patented	[12]
Tetra-hydro-oxazolopyridine derivative 4	DM21J83	N. A.	N. A.	Patented	[12]
Tetra-hydro-oxazolopyridine derivative 5	DMQGA1I	N. A.	N. A.	Patented	[12]
Tetra-hydro-oxazolopyridine derivative 6	DMLW7YO	N. A.	N. A.	Patented	[12]
Tetra-hydro-pyrazolopyrazine derivative 1	DM3HVCZ	N. A.	N. A.	Patented	[12]
Tetra-hydro-pyrazolopyrazine derivative 2	DMQ027F	N. A.	N. A.	Patented	[12]
Tetra-hydro-pyrazolopyrazine derivative 3	DMKGJ1S	N. A.	N. A.	Patented	[12]
Tetra-hydro-pyrazolopyrazine derivative 4	DMRMTF6	N. A.	N. A.	Patented	[12]
Tetra-hydro-pyrazolopyrazine derivative 5	DMAM7Y2	N. A.	N. A.	Patented	[12]
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⏷ Show the Full List of 68 Patented Agent(s)

4 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AZD2066	DMHP6OY	Chronic neuropathic pain	MG30.5	Discontinued in Phase 2	[13]
AZD2516	DM9OPDE	Chronic neuropathic pain	MG30.5	Discontinued in Phase 2	[13]
LY467711	DM0TV9L	Migraine	8A80	Terminated	[8]
LY525327	DMPNMAR	Migraine	8A80	Terminated	[8]
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264 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(+)-MCPG	DMG5QJB	Discovery agent	N.A.	Investigative	[14]
(1S,3R)-ACPD	DM5DOAF	Discovery agent	N.A.	Investigative	[14]
(3-(2-methylquinolin-7-yl)phenyl)methanol	DMR6JTQ	Discovery agent	N.A.	Investigative	[15]
(3-Ethoxy-pyridin-2-yl)-pyridin-2-yl-amine	DMG1KIJ	Discovery agent	N.A.	Investigative	[16]
(E)-1-Adamantan-1-yl-3-quinolin-3-yl-propenone	DMQ9TWD	Discovery agent	N.A.	Investigative	[17]
(E)-3-[2-(2-methyl-4-thiazolyl)vinyl]pyridine	DMITXKJ	Discovery agent	N.A.	Investigative	[18]
(S)-(+)-CBPG	DMPDOY8	Discovery agent	N.A.	Investigative	[19]
(S)-3HPG	DMQ0FVJ	Discovery agent	N.A.	Investigative	[14]
(S)-4C3HPG	DMQK4I2	Discovery agent	N.A.	Investigative	[14]
(S)-4CPG	DMZ9UIL	Discovery agent	N.A.	Investigative	[14]
1-(3-(2-methylquinolin-7-yl)phenyl)ethanone	DMD25N9	Discovery agent	N.A.	Investigative	[15]
2-(2-Methyl-thiazol-4-ylethynyl)-pyridine	DMIHTL0	Discovery agent	N.A.	Investigative	[20]
2-(2-methylquinolin-7-yl)benzonitrile	DMENUIH	Discovery agent	N.A.	Investigative	[15]
2-(3,4-dimethylphenyl)-1,8-naphthyridine	DMDGRWM	Discovery agent	N.A.	Investigative	[21]
2-(3,5-dichlorophenyl)pyrido[2,3-d]pyrimidine	DM8KM1Q	Discovery agent	N.A.	Investigative	[22]
2-(3,5-difluorophenyl)-7-methyl-1,8-naphthyridine	DMGJPYO	Discovery agent	N.A.	Investigative	[21]
2-(3,5-dimethoxyphenyl)-1,8-naphthyridine	DMKND0T	Discovery agent	N.A.	Investigative	[21]
2-(3-(2-methylquinolin-7-yl)phenyl)acetonitrile	DMLJH92	Discovery agent	N.A.	Investigative	[15]
2-(3-(3-methoxyphenoxy)prop-1-ynyl)pyridine	DM1VSOK	Discovery agent	N.A.	Investigative	[23]
2-(3-(benzyloxy)phenyl)isoindoline-1,3-dione	DM0R5U6	Discovery agent	N.A.	Investigative	[24]
2-(3-bromophenyl)-7-methyl-1,8-naphthyridine	DMYSM9L	Discovery agent	N.A.	Investigative	[21]
2-(3-bromophenyl)-7-methylpyrido[2,3-d]pyrimidine	DMANS5X	Discovery agent	N.A.	Investigative	[22]
2-(3-bromophenyl)pyrido[2,3-d]pyrimidine	DMVA4XC	Discovery agent	N.A.	Investigative	[22]
2-(3-chlorobenzyloxy)-6-chloroisonicotinonitrile	DM1VDC3	Discovery agent	N.A.	Investigative	[24]
2-(3-chlorophenyl)-7-methyl-1,8-naphthyridine	DM7BC50	Discovery agent	N.A.	Investigative	[21]
2-(4-(3-chlorophenyl)but-1-ynyl)-6-methylpyridine	DM27CQJ	Discovery agent	N.A.	Investigative	[25]
2-(m-tolylethynyl)pyrimidine	DM15BA7	Discovery agent	N.A.	Investigative	[26]
2-(phenylethynyl)pyrimidine	DMRIFCW	Discovery agent	N.A.	Investigative	[26]
2-(pyridin-2-yl)-4-(m-tolylthio)pyrimidine	DM3EBYD	Discovery agent	N.A.	Investigative	[27]
2-Benzoxy-5-(2-methylquinolin-7-yl)benzonitrile	DMQX9PD	Discovery agent	N.A.	Investigative	[7]
2-benzyloxy-7,8-dihydro-6H-quinolin-5-one	DMCLAXG	Discovery agent	N.A.	Investigative	[28]
2-bromo-4-(3-fluorophenylethynyl)thiazole	DMCM01R	Discovery agent	N.A.	Investigative	[18]
2-Chloro-5-(2-methylquinolin-7-yl)nicotinonitrile	DM5KR4B	Discovery agent	N.A.	Investigative	[7]
2-chloro-N-(3-(3-chlorobenzamido)phenyl)benzamide	DM2W71L	Discovery agent	N.A.	Investigative	[29]
2-Cyclohex-1-enylethynyl-pyridine	DM2U1N5	Discovery agent	N.A.	Investigative	[30]
2-Cyclohexylethynyl-pyridine	DM2JZ84	Discovery agent	N.A.	Investigative	[30]
2-Cyclopent-1-enylethynyl-pyridine	DMVP6CW	Discovery agent	N.A.	Investigative	[30]
2-ethoxy-5-(m-tolylethynyl)pyrimidine	DMGRA3T	Discovery agent	N.A.	Investigative	[26]
2-ethynyl-4-(3-fluorophenylethynyl)thiazole	DME6VKS	Discovery agent	N.A.	Investigative	[18]
2-m-tolyl-1,8-naphthyridine	DMBWDXH	Discovery agent	N.A.	Investigative	[21]
2-methyl-4-(2-thienylethynyl)thiazole	DMAFPE7	Discovery agent	N.A.	Investigative	[18]
2-methyl-4-(3-thienylethynyl)thiazole	DMK4A0J	Discovery agent	N.A.	Investigative	[18]
2-methyl-4-(m-tolylethynyl)thiazole	DM4P3CW	Discovery agent	N.A.	Investigative	[18]
2-Methyl-4-o-tolylethynyl-thiazole	DMKFBVS	Discovery agent	N.A.	Investigative	[20]
2-Methyl-4-p-tolylethynyl-thiazole	DMWRCFY	Discovery agent	N.A.	Investigative	[20]
2-Methyl-4-phenylethynyl-thiazole	DMRC60A	Discovery agent	N.A.	Investigative	[20]
2-methyl-6-(3-(p-tolyloxy)prop-1-ynyl)pyridine	DMGPDYE	Discovery agent	N.A.	Investigative	[23]
2-methyl-6-(3-(phenylthio)prop-1-ynyl)pyridine	DM536IA	Discovery agent	N.A.	Investigative	[25]
2-methyl-6-(4-phenylbut-1-ynyl)pyridine	DM1YK7M	Discovery agent	N.A.	Investigative	[25]
2-methyl-6-(4-phenylpent-1-ynyl)pyridine	DM0UNM1	Discovery agent	N.A.	Investigative	[25]
2-methyl-6-(5-phenylpent-1-ynyl)pyridine	DMDVO7Z	Discovery agent	N.A.	Investigative	[25]
2-methyl-6-(phenylethynyl)pyridine	DMVQK4Y	Discovery agent	N.A.	Investigative	[31], [32]
2-methyl-7-(pyridin-3-yl)quinoline	DM9FZ0B	Discovery agent	N.A.	Investigative	[15]
2-methyl-7-m-tolyl-1,6-naphthyridine	DMMFKOH	Discovery agent	N.A.	Investigative	[21]
2-methyl-7-m-tolyl-1,8-naphthyridine	DMZFK4R	Discovery agent	N.A.	Investigative	[21]
2-methyl-7-m-tolylquinoline	DMC02TI	Discovery agent	N.A.	Investigative	[15]
2-methyl-7-phenyl-1,8-naphthyridine	DM8RV5X	Discovery agent	N.A.	Investigative	[21]
2-methyl-7-phenylquinoline	DMT7MVD	Discovery agent	N.A.	Investigative	[15]
2-phenyl-1,8-naphthyridine	DM3WOHI	Discovery agent	N.A.	Investigative	[21]
2-Phenyl-5-(2-methylthiazol-4ylethynyl)pyridine	DM7A3GO	Discovery agent	N.A.	Investigative	[33]
2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-ol	DMNYOH5	Discovery agent	N.A.	Investigative	[28]
2-phenylethynyl-5,6,7,8-tetrahydro-quinoline	DM4LCRS	Discovery agent	N.A.	Investigative	[28]
2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one	DMFRQJ3	Discovery agent	N.A.	Investigative	[28]
2-[(2-methyl-4-thiazolyl)ethynyl]pyrazine	DM75WN4	Discovery agent	N.A.	Investigative	[18]
3,3'-difluorobenzaldazine	DMGMJWL	Discovery agent	N.A.	Investigative	[34]
3,5-DHPG	DMFEQ6S	Discovery agent	N.A.	Investigative	[14]
3-(1,5-naphthyridin-3-yl)benzonitrile	DM24BG6	Discovery agent	N.A.	Investigative	[21]
3-(1,8-naphthyridin-2-yl)benzonitrile	DMSP4N5	Discovery agent	N.A.	Investigative	[21]
3-(1-Pyridin-2-yl-1H-pyrazol-3-yl)-benzonitrile	DMTD7VE	Discovery agent	N.A.	Investigative	[35]
3-(1-Pyridin-2-yl-1H-pyrazol-4-yl)-benzonitrile	DMWI37C	Discovery agent	N.A.	Investigative	[35]
3-(1-Pyridin-2-yl-1H-pyrrol-3-yl)-benzonitrile	DMJ9LRE	Discovery agent	N.A.	Investigative	[35]
3-(2-methylbenzo[d]thiazol-5-yl)benzonitrile	DMY782R	Discovery agent	N.A.	Investigative	[36]
3-(2-methylquinolin-7-yl)benzonitrile	DMUPB9H	Discovery agent	N.A.	Investigative	[15]
3-(2-methylquinolin-7-yl)phenol	DM41HMZ	Discovery agent	N.A.	Investigative	[15]
3-(2-Pyridin-2-yl-2H-tetrazol-5-yl)-benzonitrile	DMPWEL8	Discovery agent	N.A.	Investigative	[35]
3-(3,4-dimethylphenyl)-1,5-naphthyridine	DMULX9O	Discovery agent	N.A.	Investigative	[21]
3-(3-(3-chlorobenzyloxy)-5-methylphenyl)pyridine	DMKAEUD	Discovery agent	N.A.	Investigative	[24]
3-(3-bromophenylethynyl)-5-methyl[1,2,4]triazine	DMFPTXO	Discovery agent	N.A.	Investigative	[37]
3-(3-methylphenylethynyl)-5-methyl[1,2,4]triazine	DMXAD0R	Discovery agent	N.A.	Investigative	[37]
3-(3-Pyridin-2-yl-pyrazol-1-yl)-benzonitrile	DMU52WA	Discovery agent	N.A.	Investigative	[35]
3-(3-Pyridin-2-yl-pyrrol-1-yl)-benzonitrile	DMZLT24	Discovery agent	N.A.	Investigative	[35]
3-(4-Pyridin-2-yl-imidazol-1-yl)-benzonitrile	DMDYVA7	Discovery agent	N.A.	Investigative	[35]
3-(4-Pyridin-2-yl-pyrazol-1-yl)-benzonitrile	DMTD16H	Discovery agent	N.A.	Investigative	[35]
3-(5-Pyridin-2-yl-tetrazol-2-yl)-benzonitrile	DMM1CKZ	Discovery agent	N.A.	Investigative	[35]
3-(6-fluoroquinazolin-4-ylamino)benzonitrile	DMHJ0SV	Discovery agent	N.A.	Investigative	[32]
3-(7-methyl-1,8-naphthyridin-2-yl)benzonitrile	DMZ53N4	Discovery agent	N.A.	Investigative	[21]
3-biphenyl-4-ylethynyl-5-methyl-[1,2,4]triazine	DMMC2Q9	Discovery agent	N.A.	Investigative	[37]
3-bromo-5-(2-methylquinolin-7-yl)benzonitrile	DMPQOS2	Discovery agent	N.A.	Investigative	[15]
3-bromo-5-[(2-methyl-4-thiazolyl)ethynyl]pyridine	DMOXY78	Discovery agent	N.A.	Investigative	[18]
3-bromo-N-(6-methylpyridin-2-yl)benzamide	DM62Y1S	Discovery agent	N.A.	Investigative	[38]
3-chloro-5-(2-methylquinolin-7-yl)benzonitrile	DMBMH96	Discovery agent	N.A.	Investigative	[15]
3-chloro-N-(3-isobutyramidophenyl)benzamide	DMV8TNO	Discovery agent	N.A.	Investigative	[29]
3-chloro-N-(4-methylthiazol-2-yl)benzamide	DM4EL6M	Discovery agent	N.A.	Investigative	[38]
3-chloro-N-(6-chloropyridin-2-yl)benzamide	DMLC2I6	Discovery agent	N.A.	Investigative	[38]
3-chloro-N-(6-methylpyridin-2-yl)benzamide	DMLJGF1	Discovery agent	N.A.	Investigative	[33]
3-cyano-5-fluoro-N-(3-fluorophenyl)benzamide	DMF1PIW	Discovery agent	N.A.	Investigative	[39]
3-cyano-5-fluoro-N-(pyridin-2-yl)benzamide	DMBA4XN	Discovery agent	N.A.	Investigative	[39]
3-cyano-5-fluoro-N-m-tolylbenzamide	DMF097H	Discovery agent	N.A.	Investigative	[39]
3-cyano-5-fluoro-N-phenylbenzamide	DMIZ8RC	Discovery agent	N.A.	Investigative	[39]
3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide	DMH7FC9	Discovery agent	N.A.	Investigative	[40], [41]
3-cyano-N-(1,4-diphenyl-1H-pyrazol-5-yl)benzamide	DM3EIWC	Discovery agent	N.A.	Investigative	[41]
3-cyano-N-(3-cyanophenyl)-5-fluorobenzamide	DMRD8VM	Discovery agent	N.A.	Investigative	[39]
3-cyano-N-(3-ethylphenyl)-5-fluorobenzamide	DMFUT57	Discovery agent	N.A.	Investigative	[39]
3-cyano-N-(3-ethynylphenyl)-5-fluorobenzamide	DM9FEMV	Discovery agent	N.A.	Investigative	[39]
3-cyano-N-(6-ethylpyridin-2-yl)-5-fluorobenzamide	DMUB9XW	Discovery agent	N.A.	Investigative	[39]
3-cyano-N-(6-methylpyridin-2-yl)benzamide	DMTDEYL	Discovery agent	N.A.	Investigative	[33]
3-ethoxy-5-(2-methylquinolin-7-yl)benzonitrile	DMSK6EM	Discovery agent	N.A.	Investigative	[15]
3-fluoro-5-(1,6-naphthyridin-7-yl)benzonitrile	DMH9VLF	Discovery agent	N.A.	Investigative	[21]
3-fluoro-5-(2-methylquinolin-7-yl)benzonitrile	DM2V45Z	Discovery agent	N.A.	Investigative	[15]
3-hydroxy-5-(2-methylquinolin-7-yl)benzonitrile	DMZS4P7	Discovery agent	N.A.	Investigative	[15]
3-iodo-N-(6-methylpyridin-2-yl)benzamide	DMDSJ0O	Discovery agent	N.A.	Investigative	[38]
3-isobutoxy-5-(2-methylquinolin-7-yl)benzonitrile	DMWP0LZ	Discovery agent	N.A.	Investigative	[15]
3-m-tolyl-1,5-naphthyridine	DMMFA4N	Discovery agent	N.A.	Investigative	[21]
3-methoxy-5-(1,5-naphthyridin-3-yl)benzonitrile	DMHYRES	Discovery agent	N.A.	Investigative	[21]
3-methoxy-5-(1,6-naphthyridin-7-yl)benzonitrile	DMKHJ8G	Discovery agent	N.A.	Investigative	[21]
3-methoxy-5-(2-methylquinolin-7-yl)benzonitrile	DMRMZLV	Discovery agent	N.A.	Investigative	[15]
3-methoxy-N-(4-methylthiazol-2-yl)benzamide	DM4WJX3	Discovery agent	N.A.	Investigative	[38]
3-methoxy-N-(6-methylpyridin-2-yl)benzamide	DMSFJNE	Discovery agent	N.A.	Investigative	[38]
3-methyl-5-(2-methylquinolin-7-yl)benzonitrile	DMM3RNV	Discovery agent	N.A.	Investigative	[15]
3-methyl-N-(6-methylpyridin-2-yl)benzamide	DMRNMKG	Discovery agent	N.A.	Investigative	[38]
3-nitro-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide	DMIZJ9G	Discovery agent	N.A.	Investigative	[41]
3-Phenyl-1-(2-methylthiazol-4-ylethynyl)benzene	DMGPOZE	Discovery agent	N.A.	Investigative	[33]
3-[(2,5-dimethyl-4-thiazolyl)ethynyl]pyridine	DMBAHRJ	Discovery agent	N.A.	Investigative	[18]
3-[(2-methyl-4-thiazolyl)ethynyl]-5-vinylpyridine	DMZ78WB	Discovery agent	N.A.	Investigative	[18]
3-[(2-methyl-4-thiazolyl)ethynyl]benzamide	DMMLDOZ	Discovery agent	N.A.	Investigative	[18]
3-[(2-methyl-4-thiazolyl)ethynyl]benzonitrile	DMQUDR1	Discovery agent	N.A.	Investigative	[42], [18]
3-[(2-methyl-4-thiazolyl)ethynyl]phenol	DMF0QM2	Discovery agent	N.A.	Investigative	[18]
3-[(5-ethyl-2-methyl-4-thiazolyl)ethynyl]pyridine	DM9OI2R	Discovery agent	N.A.	Investigative	[18]
3-[(6-Methylpyridin-2-yl)ethynyl]benzonitrile	DMH5329	Discovery agent	N.A.	Investigative	[33]
4-(2-(3-fluorophenyl)ethynyl)-2-methylthiazole	DMRDWUT	Discovery agent	N.A.	Investigative	[18]
4-(2-(4-fluorophenyl)ethynyl)-2-methylthiazole	DMOX40J	Discovery agent	N.A.	Investigative	[18]
4-(2-fluorophenylethynyl)-2-methylthiazole	DMCWZF6	Discovery agent	N.A.	Investigative	[18]
4-(2-methoxyphenylethynyl)-2-methylthiazole	DMFVYHI	Discovery agent	N.A.	Investigative	[18]
4-(2-Methyl-thiazol-4-ylethynyl)-pyridine	DMEAV9Q	Discovery agent	N.A.	Investigative	[20]
4-(3,5-difluorophenylethynyl)-2-methylthiazole	DM48Z5Y	Discovery agent	N.A.	Investigative	[18]
4-(3-bromophenoxy)-6-chloroquinazoline	DM3LGOT	Discovery agent	N.A.	Investigative	[32]
4-(3-bromophenylthio)-2-(pyridin-2-yl)pyrimidine	DMQBHF2	Discovery agent	N.A.	Investigative	[27]
4-(3-chlorophenylethynyl)-2-methylthiazole	DMDTFKL	Discovery agent	N.A.	Investigative	[18]
4-(3-chlorophenylthio)-2-(pyridin-2-yl)pyrimidine	DMJH2OE	Discovery agent	N.A.	Investigative	[27]
4-(3-fluorophenylethynyl)-2-thiazolylamine	DM6RV9L	Discovery agent	N.A.	Investigative	[18]
4-(3-methoxyphenylethynyl)-2-methylthiazole	DMGCPKU	Discovery agent	N.A.	Investigative	[18]
4-(3-pyridylethynyl)-2-thiazolylamine	DMRXKMP	Discovery agent	N.A.	Investigative	[18]
4-(4-chlorophenylthio)-2-(pyridin-2-yl)pyrimidine	DM9YRHW	Discovery agent	N.A.	Investigative	[27]
4-Biphenyl-2-ylethynyl-2-methyl-thiazole	DM3B2TG	Discovery agent	N.A.	Investigative	[20]
4-Biphenyl-4-ylethynyl-2-methyl-thiazole	DMCQYKO	Discovery agent	N.A.	Investigative	[20]
4-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide	DMJ610E	Discovery agent	N.A.	Investigative	[41]
5-((6-Methylpyridin-2-yl)ethynyl)nicotinonitrile	DMBSFLW	Discovery agent	N.A.	Investigative	[7]
5-(2-(2,5-dimethylphenyl)ethynyl)pyrimidine	DMCFKGW	Discovery agent	N.A.	Investigative	[43]
5-(2-(3,5-difluorophenyl)ethynyl)pyrimidine	DM3XMKJ	Discovery agent	N.A.	Investigative	[43]
5-(2-(3-chlorophenyl)ethynyl)pyrimidine	DM37KG6	Discovery agent	N.A.	Investigative	[43]
5-(2-(4-fluoro-3-methylphenyl)ethynyl)pyrimidine	DMRS1Q5	Discovery agent	N.A.	Investigative	[43]
5-(2-m-tolylethynyl)pyrimidine	DMO5WG8	Discovery agent	N.A.	Investigative	[43]
5-(2-Methylquinolin-7-yl)-2-phenylbenzonitrile	DMIQJM4	Discovery agent	N.A.	Investigative	[7]
5-(2-Methylquinolin-7-yl)-2-phenylnicotinonitrile	DMO74HX	Discovery agent	N.A.	Investigative	[7]
5-(2-methylquinolin-7-yl)isophthalonitrile	DMMX69H	Discovery agent	N.A.	Investigative	[15]
5-(2-methylquinolin-7-yl)nicotinonitrile	DM8LN2X	Discovery agent	N.A.	Investigative	[15]
5-(3-chlorophenylethynyl)-5-methyl[1,2,4]triazine	DMABSOC	Discovery agent	N.A.	Investigative	[37]
5-(phenylethynyl)pyrimidine	DMP4RO3	Discovery agent	N.A.	Investigative	[43]
5-Biphenyl-4-ylethynyl-pyrimidine	DMMG9PV	Discovery agent	N.A.	Investigative	[43]
5-Chloro-2-(2-methylquinolin-7-yl)benzonitrile	DMH4SLZ	Discovery agent	N.A.	Investigative	[7]
5-methyl-3-phenylethynyl[1,2,4]triazine	DMF0IJ2	Discovery agent	N.A.	Investigative	[37]
5-MPEP	DMSRGTI	Discovery agent	N.A.	Investigative	[44]
5-[(2-methyl-4-thiazolyl)ethynyl]pyrimidine	DMM9GCA	Discovery agent	N.A.	Investigative	[18]
5PAM523	DMPLB3S	Discovery agent	N.A.	Investigative	[45]
6-(4-chlorophenylamino)-N,N-diethylnicotinamide	DMOZFU5	Discovery agent	N.A.	Investigative	[46]
6-bromo-N-(3-bromophenyl)quinazolin-4-amine	DMP9O7G	Discovery agent	N.A.	Investigative	[32]
6-bromo-N-(3-chlorophenyl)quinazolin-4-amine	DM0A3DB	Discovery agent	N.A.	Investigative	[32]
6-bromo-N-(3-fluorophenyl)quinazolin-4-amine	DM2IP5F	Discovery agent	N.A.	Investigative	[32]
6-bromo-N-m-tolylquinazolin-4-amine	DM2MJ9F	Discovery agent	N.A.	Investigative	[32]
6-chloro-N-(3-chlorophenyl)quinazolin-4-amine	DMPIFLA	Discovery agent	N.A.	Investigative	[32]
6-fluoro-N-m-tolylquinazolin-4-amine	DMVADTP	Discovery agent	N.A.	Investigative	[32]
6-phenylethynyl-nicotinic acid methyl ester	DMIKRP6	Discovery agent	N.A.	Investigative	[28]
7-(2-methoxyphenyl)-2-methylquinoline	DMO8DYW	Discovery agent	N.A.	Investigative	[15]
7-(3,5-dimethoxyphenyl)-1,6-naphthyridine	DM2RFOB	Discovery agent	N.A.	Investigative	[21]
7-(3-(methoxymethyl)phenyl)-2-methylquinoline	DMYNLOI	Discovery agent	N.A.	Investigative	[15]
7-(3-chlorophenyl)-2-methylquinoline	DM0Q56N	Discovery agent	N.A.	Investigative	[15]
7-(3-fluoro-5-methylphenyl)-1,6-naphthyridine	DME2VD7	Discovery agent	N.A.	Investigative	[21]
7-(3-fluorophenyl)-2-methylquinoline	DMDXOBH	Discovery agent	N.A.	Investigative	[15]
7-(3-methoxyphenyl)-2-methyl-1,6-naphthyridine	DMEC9YK	Discovery agent	N.A.	Investigative	[21]
7-(3-methoxyphenyl)-2-methylquinoline	DMW6LCH	Discovery agent	N.A.	Investigative	[15]
7-(4,6-dimethoxypyrimidin-2-yl)-2-methylquinoline	DMHXMY5	Discovery agent	N.A.	Investigative	[36]
7-(4,6-dimethylpyrimidin-2-yl)-2-methylquinoline	DMQFBTW	Discovery agent	N.A.	Investigative	[36]
7-(4-methoxyphenyl)-2-methylquinoline	DMBT1KS	Discovery agent	N.A.	Investigative	[15]
7-(4-methoxypyrimidin-2-yl)-2-methylquinoline	DMSRKF0	Discovery agent	N.A.	Investigative	[36]
7-bromo-N-(3-bromophenyl)isoquinolin-1-amine	DML8PH7	Discovery agent	N.A.	Investigative	[32]
7-m-tolyl-1,6-naphthyridine	DMBDFP2	Discovery agent	N.A.	Investigative	[21]
7-methyl-2-m-tolylpyrido[2,3-d]pyrimidine	DMCV891	Discovery agent	N.A.	Investigative	[22]
7-methyl-2-phenylpyrido[2,3-d]pyrimidine	DMJ4G27	Discovery agent	N.A.	Investigative	[22]
ACDPP	DMPMH7Z	Discovery agent	N.A.	Investigative	[47]
ADX-63365	DMA74PO	Central nervous system disease	8A04-8D87	Investigative	[9]
alloswitch-1	DM05AYE	Discovery agent	N.A.	Investigative	[48]
BOMA	DMAW40Y	Discovery agent	N.A.	Investigative	[42]
Br-5MPEPy	DMBTC23	Discovery agent	N.A.	Investigative	[44]
CHPG	DMZ956E	Discovery agent	N.A.	Investigative	[14]
CPPHA	DMDG2Y9	Discovery agent	N.A.	Investigative	[49]
CPPZ	DM9OWG5	Discovery agent	N.A.	Investigative	[50]
CTEP	DMYRVZ8	Fragile X syndrome	LD55	Investigative	[9], [51]
GRN-529	DMJ47DM	Major depressive disorder	6A70.3	Investigative	[9]
GSK-2210875	DM0DKQN	Anxiety disorder	6B00-6B0Z	Investigative	[9]
ibotenate	DM8RZE0	Discovery agent	N.A.	Investigative	[14]
L-CCG-I	DMPZ8XH	Discovery agent	N.A.	Investigative	[14]
LSN2463359	DMWVTS3	Discovery agent	N.A.	Investigative	[52]
LSN2814617	DMV9NP6	Discovery agent	N.A.	Investigative	[52]
LY-3390334	DMUXFZQ	Discovery agent	N.A.	Investigative	[53]
M-5MPEP	DMFS7QK	Discovery agent	N.A.	Investigative	[44]
N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide	DMDW8VX	Discovery agent	N.A.	Investigative	[41]
N-(1,4-diphenyl-1H-pyrazol-5-yl)benzamide	DMEDJ7X	Discovery agent	N.A.	Investigative	[41]
N-(2-phenylimidazo[1,2-a]pyridin-3-yl)benzamide	DMUILX8	Discovery agent	N.A.	Investigative	[41]
N-(3-(3-cyanobenzamido)phenyl)-2-methoxybenzamide	DMXL70A	Discovery agent	N.A.	Investigative	[29]
N-(3-acetamidophenyl)-3-chlorobenzamide	DMH3R21	Discovery agent	N.A.	Investigative	[29]
N-(3-bromophenyl)-6-chloroquinazolin-4-amine	DMEWQCN	Discovery agent	N.A.	Investigative	[32]
N-(3-bromophenyl)-6-fluoroquinazolin-4-amine	DMRIK7P	Discovery agent	N.A.	Investigative	[32]
N-(3-chlorophenyl)-3-cyano-5-fluorobenzamide	DM3RQHG	Discovery agent	N.A.	Investigative	[39]
N-(3-chlorophenyl)-6-fluoroquinazolin-4-amine	DM3AGJH	Discovery agent	N.A.	Investigative	[32]
N-(3-chlorophenyl)-6-methoxyquinazolin-4-amine	DMQEPV0	Discovery agent	N.A.	Investigative	[32]
N-(3-chlorophenyl)-6-nitroquinazolin-4-amine	DMIKP5Y	Discovery agent	N.A.	Investigative	[32]
N-(6-methylpyridin-2-yl)-5-phenylpicolinamide	DMQRE5D	Discovery agent	N.A.	Investigative	[54]
N-(6-methylpyridin-2-yl)-6-phenylnicotinamide	DMQZMRG	Discovery agent	N.A.	Investigative	[33]
N-(6-methylpyridin-2-yl)biphenyl-3-carboxamide	DMBNJ2L	Discovery agent	N.A.	Investigative	[33]
N-cyclopentyl-6-(2-phenylethynyl)nicotinamide	DMDPKCM	Discovery agent	N.A.	Investigative	[55]
N-[4-(3-pyridylethynyl)-2-thiazolyl]acetamide	DMC62K1	Discovery agent	N.A.	Investigative	[18]
NCFP	DM0JCN2	Discovery agent	N.A.	Investigative	[56]
PMID14697765C11a	DMFWCAJ	Discovery agent	N.A.	Investigative	[42]
PMID14697765C16a	DMFT1DO	Discovery agent	N.A.	Investigative	[42]
PMID15482906C10	DM7T8BE	Discovery agent	N.A.	Investigative	[57]
PMID15482908C8	DMCPIQ4	Discovery agent	N.A.	Investigative	[58]
PMID15686941C13	DMPB7Z6	Discovery agent	N.A.	Investigative	[47]
PMID16439120C20	DMI8HAV	Discovery agent	N.A.	Investigative	[24]
PMID16439120C26	DMVM2XD	Discovery agent	N.A.	Investigative	[24]
PMID17189691C42	DMG9ZYP	Discovery agent	N.A.	Investigative	[59]
PMID17723296C18	DMBP3O7	Discovery agent	N.A.	Investigative	[22]
PMID17936624C36	DMEHC2I	Discovery agent	N.A.	Investigative	[21]
PMID19931453C16m	DM3DCR9	Discovery agent	N.A.	Investigative	[46]
PMID20598884C8	DMS21ZP	Discovery agent	N.A.	Investigative	[39]
PMID20809633C29b	DM0W6C9	Discovery agent	N.A.	Investigative	[60]
PMID21295468C47	DM0DNSV	Discovery agent	N.A.	Investigative	[61]
PMID21757343C30	DM3ELPS	Discovery agent	N.A.	Investigative	[62]
PMID21927650C18	DMLGKD3	Discovery agent	N.A.	Investigative	[63]
PMID23357634C24d	DM4NAC9	Discovery agent	N.A.	Investigative	[64]
PMID23374867C24	DMRC14X	Discovery agent	N.A.	Investigative	[65]
PMID23434029C41	DMG0XC7	Discovery agent	N.A.	Investigative	[66]
PMID23434029C53	DMG0B4N	Discovery agent	N.A.	Investigative	[66]
PTeB	DM1NM5F	Discovery agent	N.A.	Investigative	[35]
RTI-4229-982	DMG6TOA	Neurological disorder	6B60	Investigative	[9]
SIB-1757	DMFOGE2	Discovery agent	N.A.	Investigative	[38]
SIB-1893	DMAVBKP	Discovery agent	N.A.	Investigative	[38]
SP203	DM6VQZ7	Discovery agent	N.A.	Investigative	[67]
VU-1545	DMCRF48	Discovery agent	N.A.	Investigative	[41]
VU0092273	DMT76JS	Discovery agent	N.A.	Investigative	[68]
VU0240382	DMH720P	Discovery agent	N.A.	Investigative	[68]
VU0285683	DM7VCDF	Discovery agent	N.A.	Investigative	[69]
VU0357121	DMETUHS	Discovery agent	N.A.	Investigative	[70]
VU0360172	DM3NXMB	Discovery agent	N.A.	Investigative	[69]
VU0361747	DM3ZUH2	Discovery agent	N.A.	Investigative	[68]
VU0364289	DM8TR1Y	Discovery agent	N.A.	Investigative	[71]
VU0366058	DMA6CLO	Discovery agent	N.A.	Investigative	[72]
VU0404251	DMZRE6X	Discovery agent	N.A.	Investigative	[73]
VU0424465	DMZDIVL	Discovery agent	N.A.	Investigative	[74]
VU0463841	DMDW9MS	Discovery agent	N.A.	Investigative	[75]
[14C]MTEP	DMG17IU	Discovery agent	N.A.	Investigative	[76]
[3H]methoxy-PEPy	DMZ2R1O	Discovery agent	N.A.	Investigative	[77]
[3H]methoxymethyl-MTEP	DMONI13	Discovery agent	N.A.	Investigative	[76], [77]
[3H]quisqualate	DMDQBTX	Discovery agent	N.A.	Investigative	[78]
[3H]resolvin E1	DMAMK3P	N. A.	N. A.	Investigative	[15]
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⏷ Show the Full List of 264 Investigative Drug(s)

Molecular Expression Atlas (MEA) of This DTT

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This DTT

Disease Name	ICD 11	Studied Tissue	p-value	Fold-Change	Z-score
Alzheimer's disease	8A00.0	Entorhinal cortex	9.81E-07	-0.26	-0.54
Major depressive disorder	6A20	Pre-frontal cortex	8.60E-01	1.36E-02	0.06
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21	Synthesis and SAR comparison of regioisomeric aryl naphthyridines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6525-8.
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23	A new series of pyridinyl-alkynes as antagonists of the metabotropic glutamate receptor 5 (mGluR5). Bioorg Med Chem Lett. 2006 Sep 15;16(18):4792-5.
24	Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1892-7.
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