Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMP93HZ)

Drug Name

1-(3,4-dihydronaphthalen-2-yl)-1H-imidazole Drug Info

Synonyms

BRN 4745179; 89781-63-5; 1H-Imidazole, 1-(3,4-dihydro-2-naphthalenyl)-; 1-(3,4-Dihydro-2-naphthalenyl)-1H-imidazole; 1-(3,4-dihydronaphthalen-2-yl)-1H-imidazole; 1H-Imidazole,1-(3,4-dihydro-2-naphthalenyl)-; ACMC-20lqcl; Dihydronaphthalene 13; AC1MIBH1; SCHEMBL4513496; CHEMBL208471; BDBM8898; 1-(3,4-DIHYDRO-NAPHTHALEN-2-YL)-1H-IMIDAZOLE; CTK5G3471; DTXSID50237889; ZINC13684552; AKOS006279027; 1-(3,4-dihydronaphthalen-2-yl)imidazole; LS-78473

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3021558
CAS Number: CAS 89781-63-5
TTD Drug ID: DMP93HZ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Steroid 11-beta-hydroxylase (CYP11B1)	TTIQUX7	C11B1_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	5.647	4.954	5.678	6.194

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Steroid 11-beta-hydroxylase (CYP11B1)	DTT	CYP11B1	4.31E-04	-0.03	-0.13

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B... J Med Chem. 2006 Apr 6;49(7):2222-31.