General Information of Drug (ID: DMPAQLZ)

Drug Name
PMID29130358-Compound-Figure16(9b) Drug Info
Cross-matching ID
TTD Drug ID
DMPAQLZ

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Matrix metalloproteinase-13 (MMP-13) TTHY57M MMP13_HUMAN Inhibitor [1]
Matrix metalloproteinase-2 (MMP-2) TTLM12X MMP2_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Matrix metalloproteinase-2 (MMP-2) DTT MMP2 5.766 9.299 8.247 8.608
Matrix metalloproteinase-13 (MMP-13) DTT MMP13 1.263 4.603 2.138 1.963
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Matrix metalloproteinase-2 (MMP-2) DTT MMP2 1.29E-01 0.25 0.83
Matrix metalloproteinase-13 (MMP-13) DTT MMP13 1.25E-03 0.76 1.3
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46.