Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMPN314)

• Drug Name: SNA-120 Drug Info
• Synonyms: Pegcantratinib; Pegcantratinib [INN]; Pegcantratinib [USAN]; Pegcantratinib [WHO-DD]; UNII-VG44NU1168; VG44NU1168; 1233363-33-1

Indication

Disease Entry	ICD 11	Status	REF
Plaque psoriasis	EA90.0	Phase 2	[1]
Pruritus	EC90	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 132494168
  TTD Drug ID: DMPN314

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tropomyosin-related kinase A (TrkA)	TTTDVOJ	NTRK1_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tropomyosin-related kinase A (TrkA)	DTT	NTRK1	0.848	1.138	2.293	2.722

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Plaque psoriasis
• ICD Disease Classification: EA90.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tropomyosin-related kinase A (TrkA)	DTT	NTRK1	8.72E-01	-0.04	-0.22

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)