Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMPSBTL)

Drug Name
VY-AADC Drug Info
Indication
Disease Entry ICD 11 Status REF
Parkinson disease 8A00.0 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMPSBTL

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aromatic-L-amino-acid decarboxylase (DDC) TTN451K DDC_HUMAN Replacement [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Aromatic-L-amino-acid decarboxylase (DDC) DTT DDC 7.255 7.312 8.596 9.191
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Parkinson disease
ICD Disease Classification 8A00.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Aromatic-L-amino-acid decarboxylase (DDC) DTT DDC 7.84E-03 -1.49 -1.01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT03562494) VY-AADC02 for Parkinson's Disease With Motor Fluctuations (RESTORE-1). U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of Voyager Therapeutics.