Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMPSRZ0)

Drug Name

AMXT-1501 Drug Info

Synonyms

Difluoromethylornithine + polyamine transport inhibitors (head and neck cancer), Aminex Therapeutics; Polyamine transport inhibitors + polyamine biosynthesis inhibitor (head and neck cancer), Aminex Therapeutics/MediQuest Therapeutics; MQT-1426 + DFMO (head and neck cancer), Aminex Therapeutics/MediQuest Therapeutics; Polyamine-based therapy (head and neck-squamous cell carcinoma), Aminex Therapeutics/MediQuest Therapeutics

Indication

Disease Entry	ICD 11	Status	REF
Head and neck cancer	2D42	Investigative	[1]

Cross-matching ID

PubChem CID: 10144565
TTD Drug ID: DMPSRZ0

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Ornithine decarboxylase (ODC1)	TTUMGNO	DCOR_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Ornithine decarboxylase (ODC1)	DTT	ODC1	9.956	8.598	9.482	8.752

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification

02 Neoplasm

Disease Class

ICD-11: 2C82 Prostate cancer

The Studied Tissue

Head and neck tissue

The Studied Disease

Head and neck cancer [ICD-11:2C82]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Ornithine decarboxylase (ODC1)	DTT	ODC1	5.20E-35	1.58	2.43

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1276).