Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMPU7KE)

Drug Name

(4-Methyl-2-oxo-2H-quinolin-1-yl)-acetic acid Drug Info

Synonyms

103368-21-4; (4-Methyl-2-oxo-2H-quinolin-1-yl)-acetic acid; 1(2h)-quinolineacetic acid, 4-methyl-2-oxo-; NSC108456; (4-methyl-2-oxoquinolin-1(2H)-yl)acetic acid; CHEMBL64455; 2-(4-methyl-2-oxoquinolin-1(2H)-yl)acetic acid; BAS 02839786; (4-Methyl-2-oxo-1(2H)-quinolinyl)acetic acid; 2-(4-methyl-2-oxohydroquinolyl)acetic acid; AC1L6JZ1; AC1Q6I1O; MLS000714792; SCHEMBL15709048; CTK4A2028; DTXSID20296246; MolPort-001-984-878; ZINC380285; HMS2670L06; HMS1681E20; HMS3482A22; ZX-AN005388; ALBB-005471; BB_SC-06267; ZX-CM004260; BBL010328

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 268297
CAS Number: CAS 103368-21-4
TTD Drug ID: DMPU7KE

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aldose reductase (AKR1B1)	TTFBNVI	ALDR_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Aldose reductase (AKR1B1)	DTT	AKR1B1	7.436	8.652	9.874	8.066

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Aldose reductase (AKR1B1)	DTT	AKR1B1	1.08E-20	0.94	1.58

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis and aldose reductase inhibitory activity of substituted 2-oxoquinoline-1-acetic acid derivatives. J Med Chem. 1986 Oct;29(10):2024-8.