Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMPZX8U)

Drug Name
2-amino-2-(3-chlorophenyl)acetic acid Drug Info
Synonyms
7292-71-9; 2-amino-2-(3-chlorophenyl)acetic acid; Amino-(3-chloro-phenyl)-acetic acid; amino(3-chlorophenyl)acetic acid; dl-3-chlorophenylglycine; 3-chlorophenylglycine; amino-(3-chlorophenyl)acetic acid; DL-(3-Chlorophenyl)glycine; DL-2-(3-Chlorophenyl)glycine; CHEMBL204655; amino(3-chloro-phenyl)acetic acid; (R)-2-(3-Chlorophenyl)glycine; NSC154922; Benzeneacetic acid, a-amino-3-chloro-, (aS)-; PubChem20741; ACMC-20en3l; (3-chlorophenyl)glycine; AC1L6EDK; 3-Chloro-DL-phenylglycine; AC1Q3M3E; 2-(3-Chlorophenyl)glycine
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
290730
CAS Number
CAS 29884-14-8
TTD Drug ID
DMPZX8U

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) TTFK1JQ CA2D1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 5.083 4.833 5.343 2.536
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 9.36E-01 -0.03 -0.13
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1) DTT CACNA2D1 2.81E-05 -0.15 -0.68
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Structure-activity relationships of alpha-amino acid ligands for the alpha2delta subunit of voltage-gated calcium channels. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1138-41.